Universität zu Köln

Prinz, J., d'Hargues, Y., Goedel, P., Shimabukuro-Vornhagen, A., Kochanek, M. and Boell, B. (2020). CARs, CRS and neurotoxicity: severe complications after administration of immunotherapy Essentials for intensivists. Med. Klin.-Intensivmed Notfallmed., 115 (3). S. 198 - 205. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2193-6226

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Abstract

Background The development of chimeric antigen receptor (CAR) T-cells has shown promising results in relapsed/refractory B-cell acute lymphoblastic leukemia/lymphoma (B-ALL) and diffuse large cell B-cell lymphoma. Complications, especially cytokine release syndrome (CRS) and CAR T-cell related encephalopathy syndrome (CRES), can be life threatening. The management of both plays a key role in CAR T-cell therapy. Objectives Diagnosis, clinical presentation and development of complications in the treatment with CAR T-cells. Materials and methods Summary of incidence, mortality and treatment of severe complications after administration of CAR T-cells referring to current studies and therapy recommendations. Results Complications after administration of CAR T-cells, especially CRS and CRES, can be life threatening. The timely identification of side effects and their appropriate treatment usually leads to complete recovery. Conclusions Using a therapy algorithm in the treatment with CAR T-cells allows safe management of toxicities and can be helpful in recognizing them in time.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Prinz, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED d'Hargues, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goedel, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shimabukuro-Vornhagen, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochanek, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boell, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-339206
DOI:	10.1007/s00063-018-0518-7
Journal or Publication Title:	Med. Klin.-Intensivmed Notfallmed.
Volume:	115
Number:	3
Page Range:	S. 198 - 205
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2193-6226
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RECEPTOR T-CELLS; MANAGEMENT; REMISSIONS; SYSTEM; IL-6 Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33920