Universität zu Köln

Pan, Feng, El-Kashef, Dina H., Kalscheuer, Rainer, Mueller, Werner E. G., Lee, Jungho, Feldbruegge, Michael, Mandi, Attila, Kurtan, Tibor, Liu, Zhen ORCID: 0000-0003-3314-7853, Wu, Wei and Proksch, Peter (2020). Cladosins L-O, new hybrid polyketides from the endophytic fungus Cladosporium sphaerospermum WBS017. Eur. J. Med. Chem., 191. ISSY-LES-MOULINEAUX: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER. ISSN 1768-3254

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Abstract

The endophytic fungus Cladosporium sphaerospermum WBS017 was obtained from healthy bulbs of Fritillaria unibracteata var. wabuensis. Fermentation of C. sphaerospermum on solid rice medium yielded three new hybrid polyketides, cladosins L-N (1-3), and a known derivative cladodionen (4). Further cultivation of this fungus on white bean medium afforded an additional new hybrid polyketide, cladosin O (5) along with three known analogues (6-8). The structures of the new compounds were elucidated using a combination of NMR and HRESIMS data. The absolute configurations of compounds 2 and 3 were determined by Mosher's method and TDDFT-ECD calculations. All isolated compounds were evaluated for their cytotoxic and antimicrobial activities. Cladodionen (4) exhibited cytotoxicity against the mouse lymphoma cell line L5178Y with an IC50 value of 3.7 mu M, and also exhibited antifungal activity against Ustilago maydis and Saccharomyces cerevisiae, while cladosin L (1) displayed week antibacterial activity against Staphylococcus aureus ATCC 29213 and S. aureus ATCC 700699 with MIC values of 50 and 25 mu M, respectively. (c) 2020 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pan, Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED El-Kashef, Dina H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalscheuer, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Werner E. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Jungho UNSPECIFIED UNSPECIFIED UNSPECIFIED Feldbruegge, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Mandi, Attila UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurtan, Tibor UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Zhen UNSPECIFIED orcid.org/0000-0003-3314-7853 UNSPECIFIED Wu, Wei UNSPECIFIED UNSPECIFIED UNSPECIFIED Proksch, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-339282
DOI:	10.1016/j.ejmech.2020.112159
Journal or Publication Title:	Eur. J. Med. Chem.
Volume:	191
Date:	2020
Publisher:	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Place of Publication:	ISSY-LES-MOULINEAUX
ISSN:	1768-3254
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METABOLITES; ALKALOIDS Multiple languages Chemistry, Medicinal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33928