Universität zu Köln

Stavru, Fabrizia, Riemer, Jan, Jex, Aaron and Sassera, Davide (2020). When bacteria meet mitochondria: The strange case of the tick symbiont Midichloria mitochondrii(dagger). Cell Microbiol., 22 (4). HOBOKEN: WILEY. ISSN 1462-5822

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Abstract

Mitochondria are key eukaryotic organelles that perform several essential functions. Not surprisingly, many intracellular bacteria directly or indirectly target mitochondria, interfering with innate immunity, energy production or apoptosis, to make the host cell a more hospitable niche for bacterial replication. The alphaproteobacterium Midichloria mitochondrii has taken mitochondrial targeting to another level by physically colonising mitochondria, as shown by transmission electron micrographs of bacteria residing in the mitochondrial intermembrane space. This unique localization provokes a number of questions around the mechanisms allowing, and reasons driving intramitochondrial tropism. We suggest possible scenarios that could lead to this peculiar localization and hypothesize potential costs and benefits of mitochondrial colonisation for the bacterium and its host.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stavru, Fabrizia UNSPECIFIED UNSPECIFIED UNSPECIFIED Riemer, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jex, Aaron UNSPECIFIED UNSPECIFIED UNSPECIFIED Sassera, Davide UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-339564
DOI:	10.1111/cmi.13189
Journal or Publication Title:	Cell Microbiol.
Volume:	22
Number:	4
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1462-5822
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IXODES-RICINUS; HARD; FLAGELLUM; WOLBACHIA; DYNAMICS; FUSION; HOST; ENDOSYMBIONTS; PREVALENCE; WIDESPREAD Multiple languages Cell Biology; Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/33956