Universität zu Köln

Schultze-Lutter, Frauke ORCID: 0000-0003-1956-9574, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Michel, Chantal ORCID: 0000-0003-1165-6681, Kindler, Jochen ORCID: 0000-0002-9034-2770, Schimmelmann, Benno G. and Schmidt, Stefanie J. (2020). Age effects on basic symptoms in the community: A route to gain new insight into the neurodevelopment of psychosis? Eur. Arch. Psych. Clin. Neurosci., 270 (3). S. 311 - 325. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

Reports of limited clinical significance of attenuated psychotic symptoms before age 15/16 indicate an important role of neurodevelopment in the early detection of psychoses. Therefore, we examined if age also exerts an influence on the prevalence and clinical significance of the 14 cognitive and perceptive basic symptoms (BS) used in psychosis-risk criteria and conceptualized as the most direct self-experienced expression of neurobiological aberrations. A random representative general population sample of the Swiss canton Bern (N = 689, age 8-40 years, 06/2011-05/2014) was interviewed for BS, psychosocial functioning, and current mental disorder. BS were reported by 18% of participants, mainly cognitive BS (15%). In regression analyses, age affected perceptive and cognitive BS differently, indicating an age threshold for perceptive BS in late adolescence (around age 18) and for cognitive BS in young adulthood (early twenties)-with higher prevalence, but a lesser association with functional deficits and the presence of mental disorder in the below-threshold groups. Thereby, interaction effects between age and BS on functioning and mental disorder were commonly stronger than individual effects of age and BS. Indicating support of the proposed substrate-closeness of BS, differential age effects of perceptual and cognitive BS seem to follow normal brain maturation processes, in which they might occur as infrequent and temporary non-pathological disturbances. Their persistence or occurrence after conclusion of main brain maturation processes, however, might signify aberrant maturation or neurodegenerative processes. Thus, BS might provide important insight into the pathogenesis of psychosis and into differential neuroprotective or anti-inflammatory targets.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schultze-Lutter, Frauke UNSPECIFIED orcid.org/0000-0003-1956-9574 UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Michel, Chantal UNSPECIFIED orcid.org/0000-0003-1165-6681 UNSPECIFIED Kindler, Jochen UNSPECIFIED orcid.org/0000-0002-9034-2770 UNSPECIFIED Schimmelmann, Benno G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Stefanie J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-339737
DOI:	10.1007/s00406-018-0949-4
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	270
Number:	3
Page Range:	S. 311 - 325
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH-RISK; INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; CLINICAL-SIGNIFICANCE; GENERAL-POPULATION; BRAIN-DEVELOPMENT; SCHIZOPHRENIA; ADOLESCENTS; CHILDREN; PREVALENCE; PREDICTION Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33973