Universität zu Köln

Weber, Immo ORCID: 0000-0003-2979-234X, Florin, Esther ORCID: 0000-0001-8276-2508, von Papen, Michael, Visser-Vandewalle, Veerle and Timmermann, Lars (2020). Characterization of information processing in the subthalamic area of Parkinson's patients. Neuroimage, 209. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Despite advances in symptomatic treatment options the pathomechanism of idiopathic Parkinson's disease (PD) remains poorly understood. Animal studies from recent years suggest pathological information processing in the basal ganglia network to be responsible for major movement deficits observed in patients, which, according to the information lesion hypothesis, might also explain the mechanism of action of deep brain stimulation (DBS). Using novel measures from information theory we characterize the information content, storage and transfer of intraoperatively recorded local field potentials (LFP) from the subthalamic area of n = 19 PD patients undergoing surgery for implantation of electrodes for deep brain stimulation. In agreement with recent animal studies we demonstrate a significant positive correlation of subthalamic information content and movement deficits (rho > 0.48). Analysis of information storage reveals a larger processing memory in the zona incerta (ZI) than in the subthalamic nucleus (STN). We discuss possible implications for the efficiency of high frequency DBS. Further, we estimate the information transfer between forearm muscles and ZI/STN. Here, we show that the bidirectional information flow with respect to the STN is larger compared to the ZI. In contrast to the STN, however, the bidirectional information flow in the ZI is modulated, namely increased, by movement. The results of our study may help to understand the mechanism of action of deep brain stimulation and further explain recent studies claiming efficiency of ZI stimulation for certain motor symptoms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weber, Immo UNSPECIFIED orcid.org/0000-0003-2979-234X UNSPECIFIED Florin, Esther UNSPECIFIED orcid.org/0000-0001-8276-2508 UNSPECIFIED von Papen, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-339784
DOI:	10.1016/j.neuroimage.2020.116518
Journal or Publication Title:	Neuroimage
Volume:	209
Date:	2020
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; CAUDAL ZONA INCERTA; BASAL GANGLIA; OSCILLATORY ACTIVITY; MOTOR CORTEX; NUCLEUS; DISEASE; DYNAMICS; SYNCHRONIZATION; ENTROPY Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33978