Universität zu Köln

Lehmann, Helmar C., Staff, Nathan P. and Hoke, Ahmet ORCID: 0000-0003-1215-3373 (2020). Modeling chemotherapy induced peripheral neuropathy (CIPN) in vitro: Prospects and limitations. Exp. Neurol., 326. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2430

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Abstract

Neuronal cell cultures have been used as an essential tool for studying pathomechanisms of toxicity of chemotherapeutic drugs and to develop neuroprotective approaches. They offer the opportunity to dissect disease mechanisms and molecular pathways while allowing precise control of a variety of confounding factors of the physio-chemical environment. As such, a growing number of in vitro studies are published each year to decipher mechanisms of neurotoxicity of taxanes, vinca alcaloids, proteasome inhibitors and platin derivatives and/or to test neuroprotective strategies. Here, we provide a review of cell culture techniques and outcome measures that have been used in the past or are currently employed to model chemotherapy induced neuropathy in vitro. Furthermore, we discuss their advantages as well as their limitations and ways to enhance efficiency and reproducibility of cell culture studies in the field of toxic neuropathy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Staff, Nathan P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoke, Ahmet UNSPECIFIED orcid.org/0000-0003-1215-3373 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-339826
DOI:	10.1016/j.expneurol.2019.113140
Journal or Publication Title:	Exp. Neurol.
Volume:	326
Date:	2020
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2430
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DORSAL-ROOT GANGLION; NERVE GROWTH-FACTOR; MYELIN-ASSOCIATED GLYCOPROTEIN; SCHWANN-CELL CULTURES; SENSORY NEURONS; INDUCED NEUROTOXICITY; MTT ASSAY; CISPLATIN; EXPRESSION; INVOLVEMENT Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33982