Universität zu Köln

Wisgien, L., Heering, P. J., Kurschat, C. and Schmitz, M. (2020). Chronic kidney disease and peripheral arterial occlusive disease: a retrospective cohort analysis. Gefasschirurgie, 25 (4). S. 267 - 272. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1434-3932

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Abstract

Background The importance and frequency of peripheral arterial occlusive disease (PAOD) are often underestimated. In recent years a link between PAOD and chronic kidney disease (CKD) has been more and more frequently described. In dialysis patients PAOD is the most frequent reason for an amputation. Many risk factors, which are already of great importance for the development of arteriosclerosis, also play a decisive role in the development of CKD. Patients who suffer from both PAOD and CKD have a higher mortality risk than patients with only one of these diseases. Objective The aim of the study was to investigate the association between the stage of CKD and the degree of PAOD as well as the investigation of further mutual risk factors. Material and methods A retrospective observational study was conducted in 168 patients with PAOD who underwent surgical treatment in the city hospital of Solingen between 2011 and 2014. Results A marked reduction of renal function (>= CKD 3) was found in 40% of the patients. The extent of CKD was significantly higher in advanced stages of PAOD and in addition to age was associated with a higher relative chance of having an advanced stage of PAOD (odds ratio [OR] 1.933, 97.5% confidence interval [CI] 1.236-3.092 and OR 1.065, 97.5% CI 1.018-1.118). Furthermore, the extent of hyperparathyroidism increased with higher PAOD stages (30% in PAOD stage IV); however, the severity of arterial hypertension and diabetes mellitus was independent of the PAOD stage. Conclusion The primary goal in patients suffering from PAOD should be to identify the presence of CKD and when possible to consequently treat it in addition to the classical risk factors, in order to be able to delay the progression of PAOD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wisgien, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heering, P. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurschat, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-340049
DOI:	10.1007/s00772-020-00636-1
Journal or Publication Title:	Gefasschirurgie
Volume:	25
Number:	4
Page Range:	S. 267 - 272
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1434-3932
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUTRITION EXAMINATION SURVEY; CORONARY-HEART-DISEASE; PARATHYROID-HORMONE; NATIONAL-HEALTH; RISK; PREVALENCE; SMOKING Multiple languages Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34004