Universität zu Köln

Sommer, Natascha, Ghofrani, Hossein A., Pak, Oleg, Bonnet, Sebastien, Provencher, Steve, Sitbon, Olivier, Rosenkranz, Stephan, Hoeper, Marius M. and Kiely, David G. (2021). Current and future treatments of pulmonary arterial hypertension. Br. J. Pharmacol., 178 (1). S. 6 - 31. HOBOKEN: WILEY. ISSN 1476-5381

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Abstract

Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin, and NO pathways has significantly improved outcomes. However, for the vast majority of patients, PAH remains a life-limiting illness with no prospect of cure. PAH is characterised by pulmonary vascular remodelling. Current research focusses on targeting the underlying pathways of aberrant proliferation, migration, and apoptosis. Despite success in preclinical models, using a plethora of novel approaches targeting cellular GPCRs, ion channels, metabolism, epigenetics, growth factor receptors, transcription factors, and inflammation, successful transfer to human disease with positive outcomes in clinical trials is limited. This review provides an overview of novel targets addressed by clinical trials and gives an outlook on novel preclinical perspectives in PAH.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sommer, Natascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghofrani, Hossein A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pak, Oleg UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonnet, Sebastien UNSPECIFIED UNSPECIFIED UNSPECIFIED Provencher, Steve UNSPECIFIED UNSPECIFIED UNSPECIFIED Sitbon, Olivier UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenkranz, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeper, Marius M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiely, David G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-340394
DOI:	10.1111/bph.15016
Journal or Publication Title:	Br. J. Pharmacol.
Volume:	178
Number:	1
Page Range:	S. 6 - 31
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1476-5381
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CALCIUM-CHANNEL BLOCKERS; SIRTUIN 3 DEFICIENCY; CONCISE GUIDE; POTENTIAL STRATEGY; THERAPEUTIC TARGET; OXIDATIVE STRESS; ASK1 INHIBITION; IRON-DEFICIENCY; CLINICAL-TRIAL; DOUBLE-BLIND Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34039