Universität zu Köln

Schrittenlocher, Silvia, Schlereth, Simona L., Siebelmann, Sebastian, Hayashi, Takahiko ORCID: 0000-0001-8704-680X, Matthaei, Mario, Bachmann, Bjoern and Cursiefen, Claus (2020). Long-term outcome of descemet membrane endothelial keratoplasty (DMEK) following failed penetrating keratoplasty (PK). Acta Ophthalmol., 98 (7). S. E901 - 6. HOBOKEN: WILEY. ISSN 1755-3768

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Abstract

Purpose To assess the long-term outcome of Descemet membrane endothelial keratoplasty (DMEK) following failed penetrating keratoplasty (PK). Methods Retrospective review of 1840 consecutive DMEK surgeries from the prospective Cologne DMEK database performed between 07/2011 and 08/2017 at the Department of Ophthalmology, University of Cologne. Results Fifty-two eyes received a DMEK surgery after failed PK. Main indications for initial PK were Fuchs endothelial corneal dystrophy (23.1%), keratoconus and herpetic keratitis (each 15.4%). Best-corrected visual acuity (BCVA) at 3, 6 and 12 months was 0.72 +/- 0.39 (n = 33), 0.56 +/- 0.36 (n = 32) and 0.38 +/- 0.28 (n = 23), respectively. Two- and 3-year BCVA was 0.37 +/- 0.21 (n = 21) and 0.32 +/- 0.18 (n = 10). Mean improvement in visual outcome in logMAR lines was +4.3 +/- 3.4 at 6 months, +5.0 +/- 3.6 at 12 months, +6.0 +/- 2.3 at 24 months and +5.4 +/- 2.7 at 36 months, respectively. 59.6% received at least one rebubbling and 40.4% did not necessitate a rebubbling. Endothelial cell density (ECD)-decrease at 6 months was 36% (n = 17), 37% at 12 months (n = 17), 40% at 2 years (n = 8) and 32% at 3 years (n = 2). 34.6% of transplants needed a regraft. Conclusion Descemet membrane endothelial keratoplasty (DMEK) is a feasible treatment option after failed PK having a relatively good long-term outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schrittenlocher, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlereth, Simona L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebelmann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hayashi, Takahiko UNSPECIFIED orcid.org/0000-0001-8704-680X UNSPECIFIED Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-340503
DOI:	10.1111/aos.14417
Journal or Publication Title:	Acta Ophthalmol.
Volume:	98
Number:	7
Page Range:	S. E901 - 6
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1755-3768
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FAILURE Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34050