Universität zu Köln

Cruz-Jentoft, Alfonso J. ORCID: 0000-0001-7628-4861, Daragjati, Julia, Fratiglioni, Laura, Maggi, Stefania, Mangoni, Arduino A., Mattace-Raso, Francesco, Paccalin, Marc, Polidori, Maria Cristina, Topinkova, Eva, Ferrucci, Luigi and Pilotto, Alberto (2020). Using the Multidimensional Prognostic Index (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons: results and final recommendations from the MPI_AGE European Project. Aging Clin. Exp. Res., 32 (5). S. 861 - 869. NEW YORK: SPRINGER. ISSN 1720-8319

Full text not available from this repository.

Abstract

MPI_AGE is a European Union co-funded research project aimed to use the Multidimensional Prognostic Index (MPI), a validated Comprehensive Geriatric Assessment (CGA)-based prognostic tool, to develop predictive rules that guide clinical and management decisions in older people in different European countries. A series of international studies performed in different settings have shown that the MPI is useful to predict mortality and risk of hospitalization in community-dwelling older subjects at population level. Furthermore, studies performed in older people who underwent a CGA before admission to a nursing home or receiving homecare services showed that the MPI successfully identified groups of persons who could benefit, in terms of reduced mortality, of specific therapies such as statins in diabetes mellitus and coronary artery disease, anticoagulants in atrial fibrillation and antidementia drugs in cognitive decline. A prospective trial carried out in nine hospitals in Europe and Australia demonstrated that the MPI was able to predict not only in-hospital and long-term mortality, but also institutionalization, re-hospitalization and receiving homecare services during the one-year follow-up after hospital discharge. The project also explored the association between MPI and mortality in hospitalized older patients in need of complex procedures such as transcatheter aortic valve implantation or enteral tube feeding. Evidence from these studies has prompted the MPI_AGE Investigators to formulate recommendations for healthcare providers, policy makers and the general population which may help to improve the cost-effectiveness of appropriate health care interventions for older patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cruz-Jentoft, Alfonso J. UNSPECIFIED orcid.org/0000-0001-7628-4861 UNSPECIFIED Daragjati, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Fratiglioni, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Maggi, Stefania UNSPECIFIED UNSPECIFIED UNSPECIFIED Mangoni, Arduino A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mattace-Raso, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Paccalin, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Polidori, Maria Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Topinkova, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferrucci, Luigi UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilotto, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-340894
DOI:	10.1007/s40520-020-01516-0
Journal or Publication Title:	Aging Clin. Exp. Res.
Volume:	32
Number:	5
Page Range:	S. 861 - 869
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1720-8319
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPREHENSIVE GERIATRIC ASSESSMENT; ATRIAL-FIBRILLATION; TERM MORTALITY; ASSESSMENT CGA; VALIDATION; ADULTS; TOOLS Multiple languages Geriatrics & Gerontology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34089