Universität zu Köln

Aswendt, Markus ORCID: 0000-0003-1423-0934, Pallast, Niklas, Wieters, Frederique, Baues, Mayan, Hoehn, Mathias and Fink, Gereon R. ORCID: 0000-0002-8230-1856 . Lesion Size- and Location-Dependent Recruitment of Contralesional Thalamus and Motor Cortex Facilitates Recovery after Stroke in Mice. Transl. Stroke Res.. NEW YORK: SPRINGER. ISSN 1868-601X

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Abstract

Brain lesions caused by cerebral ischemia or hemorrhage lead to a local breakdown of energy homeostasis followed by irreversible cell death and long-term impairment. Importantly, local brain lesions also generate remote functional and structural disturbances, which contribute to the behavioral deficit but also impact the recovery of function. While spontaneous recovery has been associated with endogenous repair mechanisms at the vascular, neural, and immune cell levels, the impact of structural plasticity on sensory-motor dysfunction and recovery thereof remains to be elucidated by longitudinal imaging in a mouse model. Here, we applied behavioral assessments, in vivo fiber tracking, and histological validation in a photothrombotic stroke mouse model. Atlas-based whole-brain structural connectivity analysis and ex vivo histology revealed secondary neurodegeneration in the ipsilesional brain areas, mostly in the dorsal sensorimotor area of the thalamus. Furthermore, we describe for the first time a lesion size-dependent increase in structural connectivity between the contralesional primary motor cortex and thalamus with the ipsilesional cortex. The involvement of the contralesional hemisphere was associated with improved functional recovery relative to lesion size. This study highlights the importance of in vivo fiber tracking and the role of the contralesional hemisphere during spontaneous functional improvement as a potential novel stroke biomarker and therapeutic targets.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Aswendt, Markus UNSPECIFIED orcid.org/0000-0003-1423-0934 UNSPECIFIED Pallast, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieters, Frederique UNSPECIFIED UNSPECIFIED UNSPECIFIED Baues, Mayan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoehn, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-341108
DOI:	10.1007/s12975-020-00802-3
Journal or Publication Title:	Transl. Stroke Res.
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1868-601X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOCAL CEREBRAL INFARCTION; SECONDARY NEURODEGENERATION; DENDRITIC SPINES; ISCHEMIC-STROKE; REMOTE REGIONS; MOUSE-BRAIN; PLASTICITY; MRI; DIFFUSION; RAT Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34110