Universität zu Köln

Cohen-Dvashi, Hadas, Zehner, Matthias, Ehrhardt, Stefanie, Katz, Michael, Elad, Nadav, Klein, Florian and Diskin, Ron (2020). Structural Basis for a Convergent Immune Response against Ebola Virus. Cell Host Microbe, 27 (3). S. 418 - 432. CAMBRIDGE: CELL PRESS. ISSN 1934-6069

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Abstract

Ebola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The V(H)3-15/V(lambda)1-40-based class of antibodies was recently discovered to be a common response in individuals who received the Ebola virus vaccines. These antibodies display attractive properties, and thus likely contribute to the efficacy of the vaccines. Here, we use cryo-EM to elucidate how three V(H)3-15/V(lambda)1-40 antibodies from different individuals target the virus and found a convergent mechanism against a partially conserved site on the spike complex. Our study rationalizes the selection of the V(H)3-15/V(lambda)1-40 germline genes for specifically targeting this site and highlights Ebolavirus species-specific sequence divergences that may restrict breadth of V(H)3-15/V(lambda)1-40-based humoral response. The results from this study could help develop improved immunization schemes and further enable the design of immunogens that would be efficacious against a broader set of Ebolavirus species.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cohen-Dvashi, Hadas UNSPECIFIED UNSPECIFIED UNSPECIFIED Zehner, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehrhardt, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Katz, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Elad, Nadav UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Diskin, Ron UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-341195
DOI:	10.1016/j.chom.2020.01.007
Journal or Publication Title:	Cell Host Microbe
Volume:	27
Number:	3
Page Range:	S. 418 - 432
Date:	2020
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1934-6069
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POTENT NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; CONTROLLED-TRIAL; VACCINE; SEQUENCE; PROTECTION; INFECTION; DISEASE Multiple languages Microbiology; Parasitology; Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34119