Universität zu Köln

Janssens, Peter, Jouret, Francois, Bammens, Bert, Liebau, Max C., Schaefer, Franz, Dandurand, Ann, Perrone, Ronald D., Mueller, Roman-Ulrich, Pao, Christina S. and Mekahli, Djalila ORCID: 0000-0003-0954-6088 (2020). Implications of early diagnosis of autosomal dominant polycystic kidney disease: A post hoc analysis of the TEMPO 3:4 trial. Sci Rep, 10 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

It is unknown whether early diagnosis of autosomal dominant polycystic kidney disease (ADPKD) can enable earlier management and improve outcomes. We conducted a post hoc analysis of data from the TEMPO 3:4 trial. Subjects were stratified by ADPKD diagnosis at age =18 (childhood diagnosis [CD]) or>18 (adulthood diagnosis [AD]). Groups were compared for baseline characteristics and total kidney volume (TKV) growth and estimated glomerular filtration rate (eGFR) decline over 3 years. 294 CD and 1148 AD subjects were analyzed. At inclusion, CD subjects were younger (mean age 34.2 versus 39.8 years; p < 0.0001) and had better eGFR (mean +/- SD 87.4 +/- 23.9 versus 80.1 +/- 20.7 mL/min/1.73 m(2); p < 0.0001), while CD had more severe Mayo risk classification (p < 0.0001) and more PKD1 mutations (p = 0.003). No statistical differences were found in TKV or eGFR change. At study end, placebo-treated CD subjects had better eGFR than projected by a prediction equation (mean difference +/- SD for observed versus predicted eGFR: 2.18 +/- 10.7 mL/min/1.73 m(2); p = 0.0475). However, these results are not confirmed when excluding stage 1 CKD. Whether CD subjects, despite their risk profile, have a slower disease course than predicted remains inconclusive. Future studies are needed to confirm that early diagnosis and management can alter the disease course of ADPKD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Janssens, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Jouret, Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED Bammens, Bert UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebau, Max C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED Dandurand, Ann UNSPECIFIED UNSPECIFIED UNSPECIFIED Perrone, Ronald D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Pao, Christina S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mekahli, Djalila UNSPECIFIED orcid.org/0000-0003-0954-6088 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-341283
DOI:	10.1038/s41598-020-61303-9
Journal or Publication Title:	Sci Rep
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLOMERULAR HYPERFILTRATION; TOLVAPTAN; VOLUME; PROGRESSION; CHILDREN Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34128