Universität zu Köln

Betkiewicz, Rinaldo, Lindner, Benjamin and Nawrot, Martin P. (2020). Circuit and Cellular Mechanisms Facilitate the Transformation from Dense to Sparse Coding in the Insect Olfactory System. eNeuro, 7 (2). WASHINGTON: SOC NEUROSCIENCE. ISSN 2373-2822

Full text not available from this repository.

Abstract

Transformations between sensory representations are shaped by neural mechanisms at the cellular and the circuit level. In the insect olfactory system, the encoding of odor information undergoes a transition from a dense spatiotemporal population code in the antennal lobe to a sparse code in the mushroom body. However, the exact mechanisms shaping odor representations and their role in sensory processing are incompletely identified. Here, we investigate the transformation from dense to sparse odor representations in a spiking model of the insect olfactory system, focusing on two ubiquitous neural mechanisms: spike frequency adaptation at the cellular level and lateral inhibition at the circuit level. We find that cellular adaptation is essential for sparse representations in time (temporal sparseness), while lateral inhibition regulates sparseness in the neuronal space (population sparseness). The interplay of both mechanisms shapes spatio-temporal odor representations, which are optimized for the discrimination of odors during stimulus onset and offset. Response pattern correlation across different stimuli showed a nonmonotonic dependence on the strength of lateral inhibition with an optimum at intermediate levels, which is explained by two counteracting mechanisms. In addition, we find that odor identity is stored on a prolonged timescale in the adaptation levels but not in the spiking activity of the principal cells of the mushroom body, providing a testable hypothesis for the location of the so-called odor trace.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Betkiewicz, Rinaldo UNSPECIFIED UNSPECIFIED UNSPECIFIED Lindner, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Nawrot, Martin P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-341872
DOI:	10.1523/ENEURO.0305-18.2020
Journal or Publication Title:	eNeuro
Volume:	7
Number:	2
Date:	2020
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	2373-2822
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MUSHROOM BODY; ANTENNAL LOBE; ODOR REPRESENTATIONS; GABAERGIC INHIBITION; LOCAL INTERNEURONS; NETWORK MECHANISMS; KENYON CELLS; NEURONS; HONEYBEE; DYNAMICS Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34187