Universität zu Köln

van Koningsbruggen-Rietschel, Silke, Conrath, Katja, Fischer, Rainald, Sutharsan, Sivagurunathan, Kempa, Axel, Gleiber, Wolfgang, Schwarz, Carsten, Hector, Andreas, Van Osselaer, Nancy, Pano, Arian, Corveleyn, Sam, Bwirire, Dieudonne, Santermans, Eva, Muller, Karine, Bellaire, Susan and Van de Steen, Olivier (2020). GLPG2737 in lumacaftor/ivacaftor-treated CF subjects homozygous for the F508del mutation: A randomized phase 2A trial (PELICAN). J. Cyst. Fibros, 19 (2). S. 292 - 299. AMSTERDAM: ELSEVIER. ISSN 1873-5010

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Abstract

Background: Triple combinations of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulators demonstrate enhanced clinical efficacy in CF patients with F508del mutation, compared with modest effects of dual combinations. GLPG2737 was developed as a novel corrector for triple combination therapy. Methods: This multicenter, randomized, double-blind, placebo-controlled, phase 2a study evaluated GLPG2737 in F508del homozygous subjects who had been receiving lumacaftor 400 mg/ivacaftor 250 mg for >= 12 weeks. The primary outcome was change from baseline in sweat chloride concentration. Other outcomes included assessment of pulmonary function, respiratory symptoms, safety, tolerability, and pharmacokinetics. Results: Between November 2017 and April 2018, 22 subjects were enrolled and randomized to oral GLPG2737 (75 mg; n = 14) or placebo (n = 8) capsules twice daily for 28 days. A significant decrease from baseline in mean sweat chloride concentration occurred at day 28 for GLPG2737 versus placebo (least-squares-mean difference - 19.6 mmol/L [95% confidence interval (CI) -36.0, -3.2], p = .0210). The absolute improvement, as assessed by least-squares-mean difference in change from baseline, in forced expiratory volume in 1 s (percent predicted) at day 28 for GLPG2737 versus placebo was 3.4% (95% CI -0.5, 7.3). Respiratory symptoms in both groups remained stable. Mild/moderate adverse events occurred in 10 (71.4%) and 8 (100%) subjects receiving GLPG2737 and placebo, respectively. Lower exposures of GLPG2737 (and active metabolite M4) were observed than would be expected if administered alone (as lumacaftor induces CYP3A4). Lumacaftor and ivacaftor exposures were as expected. Conclusions: GLPG2737 was well tolerated and yielded significant decreases in sweat chloride concentration versus placebo in subjects homozygous for F508del receiving lumacaftor/ivacaftor, demonstrating evidence of increased CFTR activity when added to a potentiator-corrector combination. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Koningsbruggen-Rietschel, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Conrath, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Rainald UNSPECIFIED UNSPECIFIED UNSPECIFIED Sutharsan, Sivagurunathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kempa, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Gleiber, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Hector, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Osselaer, Nancy UNSPECIFIED UNSPECIFIED UNSPECIFIED Pano, Arian UNSPECIFIED UNSPECIFIED UNSPECIFIED Corveleyn, Sam UNSPECIFIED UNSPECIFIED UNSPECIFIED Bwirire, Dieudonne UNSPECIFIED UNSPECIFIED UNSPECIFIED Santermans, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Muller, Karine UNSPECIFIED UNSPECIFIED UNSPECIFIED Bellaire, Susan UNSPECIFIED UNSPECIFIED UNSPECIFIED Van de Steen, Olivier UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-341917
DOI:	10.1016/j.jcf.2019.09.006
Journal or Publication Title:	J. Cyst. Fibros
Volume:	19
Number:	2
Page Range:	S. 292 - 299
Date:	2020
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-5010
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYSTIC-FIBROSIS; IVACAFTOR; COMBINATION Multiple languages Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34191