Universität zu Köln

Taucher, Christian, Barnett, Elizabeth D., Cramer, Jakob P., Eder-Lingelbach, Susanne, Jelinek, Tomas, Kadlecek, Vera, Kiermayr, Sigrid, Mills, Deborah J., Pandis, Duellyn, Reiner, Daniela and Dubischar, Katrin L. (2020). Neutralizing antibody persistence in pediatric travelers from non-JE-endemic countries following vaccination with IXIARO (R) Japanese encephalitis vaccine: An uncontrolled, open-label phase 3 follow-up study. Travel Med. Infect. Dis., 34. OXFORD: ELSEVIER SCI LTD. ISSN 1873-0442

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Abstract

Background: In an initial study among children from non-Japanese encephalitis (JE)-endemic countries, seroprotection rates remained high 6 months after completion of the primary series with IXIARO (R). Methods: In this open-label follow-up study, a subset of 23 children who received a 2-dose primary series of IXIARO (R) in the parent study, were evaluated for safety and neutralizing antibody persistence for 36 months. Results: Seroprotection rates (SPRs) remained high but declined from 100% one month after primary immunization to 91.3% at month 7 and 89.5% at month 36. Geometric mean titers (GMTs) declined considerably from 384.1 by day 56-60.8 at month 36. No long-term safety concerns were identified. Conclusions: The substantial decline in GMT observed in this study, together with previously published data on children vaccinated with IXIARO (R) support the recommendation for a booster dose in children who remain at risk of JE from 1 year after the primary series of IXIARO (R), consistent with the recommendation for adults.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Taucher, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Barnett, Elizabeth D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cramer, Jakob P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eder-Lingelbach, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Jelinek, Tomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kadlecek, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiermayr, Sigrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Mills, Deborah J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pandis, Duellyn UNSPECIFIED UNSPECIFIED UNSPECIFIED Reiner, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Dubischar, Katrin L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-342058
DOI:	10.1016/j.tmaid.2020.101616
Journal or Publication Title:	Travel Med. Infect. Dis.
Volume:	34
Date:	2020
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-0442
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHILDREN Multiple languages Public, Environmental & Occupational Health; Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34205