Universität zu Köln

Ortiz-Bruechle, N., Muders, M., Toma, M., Esposito, I, Hartmann, A., Stoehr, R., Reis, H., Wild, P., Koellermann, J., Bremmer, F., Leichsenring, J., Stenzinger, A., Merkelbach-Bruse, S., Kirfel, S., Perner, S., Hartmann, N., Roth, W., Jung, A., Kirchner, T., Schwamborn, K., Pfarr, N., Dahl, E., Knuechel, R. and Gaisa, N. T. (2020). Status of the availability and use of next generation sequencing (NGS) in bladder cancer-a questionnaire within the uropathology working group. Urologe, 59 (3). S. 318 - 326. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0563

Full text not available from this repository.

Abstract

Background Technical advancement and availability of high-throughput analysis has advanced molecular subtyping of most cancers. Thus, new possibilities for precision oncology have emerged. Aim Therefore, we aimed to collect data regarding availability and use of next generation sequencing (NGS) for urothelial cancer within the uropathology working group of the German Society of Pathology. Methods We collected data by questionnaires and additionally asked for sequencing results of bladder cancers in the participating institutions. Results A total of 13 university-affiliated institutes of pathology took part in the survey. All university institutes offer NGS-based molecular panel diagnostics and provide panels covering between 15 and 170 genes. Altogether, only 20 bladder cancers were sequenced in routine diagnostics and for 10 cancers potential targeted treatment options were available. Discussion So far, despite availability of NGS diagnostics at university institutes of pathology, only few bladder cancer samples have been sequenced. Based on current data from the molecular subtyping of bladder cancers, we recommend a step-by-step protocol with basic immunohistochemistry analysis and subsequent subtype-dependent analyses, e.g., alterations of the fibroblast growth factor receptors (FGFR) or comprehensive gene panel analyses.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ortiz-Bruechle, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Muders, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Toma, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Esposito, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoehr, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reis, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wild, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koellermann, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bremmer, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leichsenring, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stenzinger, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkelbach-Bruse, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirfel, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Perner, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roth, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchner, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwamborn, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfarr, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dahl, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knuechel, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaisa, N. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-342876
DOI:	10.1007/s00120-019-01046-2
Journal or Publication Title:	Urologe
Volume:	59
Number:	3
Page Range:	S. 318 - 326
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0563
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPREHENSIVE MOLECULAR CHARACTERIZATION; ASSOCIATION; VARIANTS; TAXONOMY; SUBTYPES Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34287