Universität zu Köln

Shahbazi, Mohammad-Ali ORCID: 0000-0002-4860-3017, Faghfouri, Leila, Ferreira, Monica P. A., Figueiredo, Patricia ORCID: 0000-0002-3689-3280, Maleki, Hajar ORCID: 0000-0002-2813-4700, Sefat, Farshid, Hirvonen, Jouni and Santos, Helder A. (2020). The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties. Chem. Soc. Rev., 49 (4). S. 1253 - 1322. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1460-4744

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Abstract

Studies of nanosized forms of bismuth (Bi)-containing materials have recently expanded from optical, chemical, electronic, and engineering fields towards biomedicine, as a result of their safety, cost-effective fabrication processes, large surface area, high stability, and high versatility in terms of shape, size, and porosity. Bi, as a nontoxic and inexpensive diamagnetic heavy metal, has been used for the fabrication of various nanoparticles (NPs) with unique structural, physicochemical, and compositional features to combine various properties, such as a favourably high X-ray attenuation coefficient and near-infrared (NIR) absorbance, excellent light-to-heat conversion efficiency, and a long circulation half-life. These features have rendered bismuth-containing nanoparticles (BiNPs) with desirable performance for combined cancer therapy, photothermal and radiation therapy (RT), multimodal imaging, theranostics, drug delivery, biosensing, and tissue engineering. Bismuth oxyhalides (BiOx, where X is Cl, Br or I) and bismuth chalcogenides, including bismuth oxide, bismuth sulfide, bismuth selenide, and bismuth telluride, have been heavily investigated for therapeutic purposes. The pharmacokinetics of these BiNPs can be easily improved via the facile modification of their surfaces with biocompatible polymers and proteins, resulting in enhanced colloidal stability, extended blood circulation, and reduced toxicity. Desirable antibacterial effects, bone regeneration potential, and tumor growth suppression under NIR laser radiation are the main biomedical research areas involving BiNPs that have opened up a new paradigm for their future clinical translation. This review emphasizes the synthesis and state-of-the-art progress related to the biomedical applications of BiNPs with different structures, sizes, and compositions. Furthermore, a comprehensive discussion focusing on challenges and future opportunities is presented.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shahbazi, Mohammad-Ali UNSPECIFIED orcid.org/0000-0002-4860-3017 UNSPECIFIED Faghfouri, Leila UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferreira, Monica P. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Figueiredo, Patricia UNSPECIFIED orcid.org/0000-0002-3689-3280 UNSPECIFIED Maleki, Hajar UNSPECIFIED orcid.org/0000-0002-2813-4700 UNSPECIFIED Sefat, Farshid UNSPECIFIED UNSPECIFIED UNSPECIFIED Hirvonen, Jouni UNSPECIFIED UNSPECIFIED UNSPECIFIED Santos, Helder A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-344277
DOI:	10.1039/c9cs00283a
Journal or Publication Title:	Chem. Soc. Rev.
Volume:	49
Number:	4
Page Range:	S. 1253 - 1322
Date:	2020
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1460-4744
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RAY COMPUTED-TOMOGRAPHY; NEAR-INFRARED LIGHT; GUIDED PHOTOTHERMAL THERAPY; SCREEN-PRINTED ELECTRODES; STRIPPING VOLTAMMETRIC MEASUREMENT; ENHANCED PHOTOCATALYTIC ACTIVITY; MICROWAVE-HYDROTHERMAL SYNTHESIS; COPPER SULFIDE NANOPARTICLES; TUMOR-ASSOCIATED MACROPHAGES; MINERAL TRIOXIDE AGGREGATE Multiple languages Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34427