Engel, Christoph ORCID: 0000-0002-7247-282X, Fischer, Christine, Zachariae, Silke, Bucksch, Karolin, Rhiem, Kerstin, Giesecke, Jutta, Herold, Natalie, Wappenschmidt, Barbara, Huebbel, Verena, Maringa, Monika, Reichstein-Gnielinski, Simone, Hahnen, Eric, Bartram, Claus R., Dikow, Nicola, Schott, Sarah, Speiser, Dorothee, Horn, Denise, Fallenberg, Eva M., Kiechle, Marion, Quante, Anne S., Vesper, Anne-Sophie, Fehm, Tanja, Mundhenke, Christoph, Arnold, Norbert, Leinert, Elena, Just, Walter, Siebers-Renelt, Ulrike, Weigel, Stefanie, Gehrig, Andrea, Woeckel, Achim, Schlegelberger, Brigitte, Pertschy, Stefanie, Kast, Karin, Wimberger, Pauline, Briest, Susanne, Loeffler, Markus, Bick, Ulrich and Schmutzler, Rita K. (2020). Breast cancer risk inBRCA1/2mutation carriers and noncarriers under prospective intensified surveillance. Int. J. Cancer, 146 (4). S. 999 - 1010. HOBOKEN: WILEY. ISSN 1097-0215

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Abstract

Comparably little is known about breast cancer (BC) risks in women from families tested negative forBRCA1/2mutations despite an indicative family history, as opposed toBRCA1/2mutation carriers. We determined the age-dependent risks of first and contralateral breast cancer (FBC, CBC) both in noncarriers and carriers ofBRCA1/2mutations, who participated in an intensified breast imaging surveillance program. The study was conducted between January 1, 2005, and September 30, 2017, at 12 university centers of the German Consortium for Hereditary Breast and Ovarian Cancer. Two cohorts were prospectively followed up for incident FBC (n= 4,380; 16,398 person-years [PY], median baseline age: 39 years) and CBC (n= 2,993; 10,090 PY, median baseline age: 42 years). Cumulative FBC risk at age 60 was 61.8% (95% CI 52.8-70.9%) forBRCA1mutation carriers, 43.2% (95% CI 32.1-56.3%) forBRCA2mutation carriers and 15.7% (95% CI 11.9-20.4%) for noncarriers. FBC risks were significantly higher than in the general population, with incidence rate ratios of 23.9 (95% CI 18.9-29.8) forBRCA1mutation carriers, 13.5 (95% CI 9.2-19.1) forBRCA2mutation carriers and 4.9 (95% CI 3.8-6.3) forBRCA1/2noncarriers. Cumulative CBC risk 10 years after FBC was 25.1% (95% CI 19.6-31.9%) forBRCA1mutation carriers, 6.6% (95% CI 3.4-12.5%) forBRCA2mutation carriers and 3.6% (95% CI 2.2-5.7%) for noncarriers. CBC risk in noncarriers was similar to women with unilateral BC from the general population. Further studies are needed to confirm whether less intensified surveillance is justified in women fromBRCA1/2negative families with elevated risk.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
Fischer, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zachariae, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bucksch, KarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rhiem, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giesecke, JuttaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herold, NatalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wappenschmidt, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huebbel, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maringa, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reichstein-Gnielinski, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hahnen, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartram, Claus R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dikow, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schott, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Speiser, DorotheeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, DeniseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fallenberg, Eva M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiechle, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quante, Anne S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vesper, Anne-SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehm, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mundhenke, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arnold, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leinert, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Just, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siebers-Renelt, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weigel, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gehrig, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woeckel, AchimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlegelberger, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pertschy, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kast, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wimberger, PaulineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Briest, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loeffler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bick, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-344742
DOI: 10.1002/ijc.32396
Journal or Publication Title: Int. J. Cancer
Volume: 146
Number: 4
Page Range: S. 999 - 1010
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-0215
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OVARIAN-CANCER; BRCA2 MUTATIONS; FAMILY-HISTORY; GERMLINE MUTATIONS; HEREDITARY BREAST; CUMULATIVE RISK; LARGE SERIES; AGE; WOMENMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34474

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