Universität zu Köln

Halbach, Marcel, Grothaus, David, Hoffmann, Fabian ORCID: 0000-0002-3199-9924, Madershahian, Navid, Kuhr, Kathrin and Reuter, Hannes (2020). Baroreflex activation therapy reduces frequency and duration of hypertension-related hospitalizations in patients with resistant hypertension. Clin. Auton. Res., 30 (6). S. 541 - 549. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1619-1560

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Abstract

Purpose Baroreflex activation therapy (BAT) has been shown to lower blood pressure in patients with resistant hypertension. The purpose of this study was to analyze whether this translates into a reduction of more relevant clinical endpoints. Methods Patients with resistant hypertension were treated with the second-generation BAT system. Records on hospitalization (dates of admission and discharge, main diagnosis) were obtained from medical insurance companies. Results Records on hospitalization were available for a period of 1 year before BAT in two patients and 2 years in 22 patients. The total number of hospitalizations per patient was 3.3 +/- 3.5/year before BAT and 2.2 +/- 2.7/year after BAT (p = 0.03). Hospitalizations related to hypertension were significantly decreased from 1.5 +/- 1.6/year before BAT to 0.5 +/- 0.9/year after BAT (p < 0.01). The cumulative duration of hypertension-related hospital stays was significantly reduced from 8.0 +/- 8.7 days/year before BAT to 1.8 +/- 4.8 days/year after BAT (p < 0.01). Office cuff blood pressure was 183 +/- 27 mmHg over 102 +/- 17 mmHg under 6.6 +/- 2.0 antihypertensive drugs before BAT and 157 +/- 32 mmHg over 91 +/- 20 mmHg (both p < 0.01) under 5.9 +/- 1.9 antihypertensive drugs (p = 0.09 for number of drugs) at latest follow-up. Daytime ambulatory blood pressure was 164 +/- 21 mmHg over 91 +/- 14 mmHg before BAT and 153 +/- 21 mmHg (p = 0.03) over 89 +/- 15 mmHg (p = 0.56) at latest follow-up. Heart rate was 75 +/- 16 bpm before BAT and 72 +/- 12 bpm at latest follow-up (p = 0.35). Conclusions Rate and duration of hypertension-related hospitalizations in patients with severe resistant hypertension were lowered after BAT. Whether the response is mediated through improvements in blood pressure control requires further studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Halbach, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Grothaus, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Fabian UNSPECIFIED orcid.org/0000-0002-3199-9924 UNSPECIFIED Madershahian, Navid UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhr, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, Hannes UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-344941
DOI:	10.1007/s10286-020-00670-9
Journal or Publication Title:	Clin. Auton. Res.
Volume:	30
Number:	6
Page Range:	S. 541 - 549
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1619-1560
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOWERS BLOOD-PRESSURE; MEDICATION ADHERENCE; RENAL DENERVATION; MORTALITY; REDUCTION; FAILURE; SYSTEM; TRIAL Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34494