Universität zu Köln

Warth Perez Arias, Carmina Carelia, Frosch, Patrizia, Fiala, Andre ORCID: 0000-0002-9745-5145 and Riemensperger, Thomas D. (2020). Stochastic and Arbitrarily Generated Input Patterns to the Mushroom Bodies Can Serve as Conditioned Stimuli in Drosophila. Front. Physiol., 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-042X

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Abstract

Single neurons in the brains of insects often have individual genetic identities and can be unambiguously identified between animals. The overall neuronal connectivity is also genetically determined and hard-wired to a large degree. Experience-dependent structural and functional plasticity is believed to be superimposed onto this more-or-less fixed connectome. However, in Drosophila melanogaster, it has been shown that the connectivity between the olfactory projection neurons (OPNs) and Kenyon cells, the intrinsic neurons of the mushroom body, is highly stochastic and idiosyncratic between individuals. Ensembles of distinctly and sparsely activated Kenyon cells represent information about the identity of the olfactory input, and behavioral relevance can be assigned to this representation in the course of associative olfactory learning. Previously, we showed that in the absence of any direct sensory input, artificially and stochastically activated groups of Kenyon cells could be trained to encode aversive cues when their activation coincided with aversive stimuli. Here, we have tested the hypothesis that the mushroom body can learn any stochastic neuronal input pattern as behaviorally relevant, independent of its exact origin. We show that fruit flies can learn thermogenetically generated, stochastic activity patterns of OPNs as conditioned stimuli, irrespective of glomerular identity, the innate valence that the projection neurons carry, or inter-hemispheric symmetry.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Warth Perez Arias, Carmina Carelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Frosch, Patrizia UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiala, Andre UNSPECIFIED orcid.org/0000-0002-9745-5145 UNSPECIFIED Riemensperger, Thomas D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-344985
DOI:	10.3389/fphys.2020.00053
Journal or Publication Title:	Front. Physiol.
Volume:	11
Date:	2020
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-042X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SPATIAL REPRESENTATION; OLFACTORY INPUTS; IMAGING REVEALS; VISUAL INPUT; BODY; MAP; ORGANIZATION; NEURONS; INTEGRATION; CALYX Multiple languages Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34498