Bazzi, Wael, Abou Fayad, Antoine G., Nasser, Aya, Haraoui, Louis-Patrick, Dewachi, Omar, Abou-Sitta, Ghassan, Nguyen, Vinh-Kim, Abara, Aula, Karah, Nabil, Landecker, Hannah ORCID: 0000-0002-1282-9962, Knapp, Charles ORCID: 0000-0001-7997-8543, McEvoy, Megan M., Zaman, Muhammad H., Higgins, Paul G. ORCID: 0000-0001-8677-9454 and Matar, Ghassan M. (2020). Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms. Front. Microbiol., 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-302X

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Abstract

Acinetobacter baumannii has become increasingly resistant to leading antimicrobial agents since the 1970s. Increased resistance appears linked to armed conflicts, notably since widespread media stories amplified clinical reports in the wake of the American invasion of Iraq in 2003. Antimicrobial resistance is usually assumed to arise through selection pressure exerted by antimicrobial treatment, particularly where treatment is inadequate, as in the case of low dosing, substandard antimicrobial agents, or shortened treatment course. Recently attention has focused on an emerging pathogen, multi-drug resistant A. baumannii (MDRAb). MDRAb gained media attention after being identified in American soldiers returning from Iraq and treated in US military facilities, where it was termed Iraqibacter. However, MDRAb is strongly associated in the literature with war injuries that are heavily contaminated by both environmental debris and shrapnel from weapons. Both may harbor substantial amounts of toxic heavy metals. Interestingly, heavy metals are known to also select for antimicrobial resistance. In this review we highlight the potential causes of antimicrobial resistance by heavy metals, with a focus on its emergence in A. baumanni in war zones.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bazzi, WaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abou Fayad, Antoine G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nasser, AyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haraoui, Louis-PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dewachi, OmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abou-Sitta, GhassanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nguyen, Vinh-KimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abara, AulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karah, NabilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landecker, HannahUNSPECIFIEDorcid.org/0000-0002-1282-9962UNSPECIFIED
Knapp, CharlesUNSPECIFIEDorcid.org/0000-0001-7997-8543UNSPECIFIED
McEvoy, Megan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zaman, Muhammad H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Higgins, Paul G.UNSPECIFIEDorcid.org/0000-0001-8677-9454UNSPECIFIED
Matar, Ghassan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-345582
DOI: 10.3389/fmicb.2020.00068
Journal or Publication Title: Front. Microbiol.
Volume: 11
Date: 2020
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1664-302X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COPPER-RESISTANCE; ACINETOBACTER-BAUMANNII; CHROMIUM RESISTANCE; CHROMATE RESISTANCE; LEAD RESISTANCE; EFFLUX SYSTEM; BACTERIA; ASSOCIATION; MERCURY; STRAINMultiple languages
MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34558

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