Chen, Jianbin ORCID: 0000-0002-9430-5838, Yang, Hechuan, Teo, Audrey Su Min, Amer, Lidyana Bte, Sherbaf, Faranak Ghazi, Tan, Chu Quan, Alvarez, Jacob Josiah Santiago, Lu, Bingxin, Lim, Jia Qi, Takano, Angela, Nahar, Rahul, Lee, Yin Yeng, Phual, Cheryl Zi Jin, Chua, Khi Pin ORCID: 0000-0002-0083-0181, Suteja, Lisda, Chen, Pauline Jieqi, Chang, Mei Mei, Koh, Tina Puay Theng, Ong, Boon-Hean, Anantham, Devanand, Hsu, Anne Ann Ling, Gogna, Apoorva, Too, Chow Wei ORCID: 0000-0002-0073-1554, Aung, Zaw Win, Lee, Yi Fei, Wang, Lanying ORCID: 0000-0002-5414-0055, Lim, Tony Kiat Hon, Wilm, Andreas, Choi, Poh Sum, Ng, Poh Yong, Toh, Chee Keong, Lim, Wan-Teck ORCID: 0000-0002-4655-0206, Ma, Siming ORCID: 0000-0002-1810-8357, Lim, Bing, Liu, Jin ORCID: 0000-0002-5707-2078, Tam, Wai Leong ORCID: 0000-0003-2365-5264, Skanderup, Anders Jacobsen, Yeong, Joe Poh Sheng, Tan, Eng-Huat, Creasy, Caretha L., Tan, Daniel Shao Weng, Hillmer, Axel M. and Zhai, Weiwei ORCID: 0000-0001-7938-0226 (2020). Genomic landscape of lung adenocarcinoma in East Asians. Nature Genet., 52 (2). S. 177 - 200. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1718

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Abstract

Lung cancer is the world's leading cause of cancer death and shows strong ancestry disparities. By sequencing and assembling a large genomic and transcriptomic dataset of lung adenocarcinoma (LUAD) in individuals of East Asian ancestry (EAS; n = 305), we found that East Asian LUADs had more stable genomes characterized by fewer mutations and fewer copy number alterations than LUADs from individuals of European ancestry. This difference is much stronger in smokers as compared to nonsmokers. Transcriptomic clustering identified a new EAS-specific LUAD subgroup with a less complex genomic profile and upregulated immune-related genes, allowing the possibility of immunotherapy-based approaches. Integrative analysis across clinical and molecular features showed the importance of molecular phenotypes in patient prognostic stratification. EAS LUADs had better prediction accuracy than those of European ancestry, potentially due to their less complex genomic architecture. This study elucidated a comprehensive genomic landscape of EAS LUADs and highlighted important ancestry differences between the two cohorts. Genomic and transcriptomic analysis of lung adenocarcinoma (LUAD) in Asia indicates that Asian LUADs have fewer mutations, lower driver prevalence and fewer copy number alterations than European LUADs.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Chen, JianbinUNSPECIFIEDorcid.org/0000-0002-9430-5838UNSPECIFIED
Yang, HechuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teo, Audrey Su MinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amer, Lidyana BteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sherbaf, Faranak GhaziUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, Chu QuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez, Jacob Josiah SantiagoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lu, BingxinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lim, Jia QiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Takano, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nahar, RahulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Yin YengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phual, Cheryl Zi JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chua, Khi PinUNSPECIFIEDorcid.org/0000-0002-0083-0181UNSPECIFIED
Suteja, LisdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, Pauline JieqiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang, Mei MeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koh, Tina Puay ThengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ong, Boon-HeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anantham, DevanandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hsu, Anne Ann LingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gogna, ApoorvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Too, Chow WeiUNSPECIFIEDorcid.org/0000-0002-0073-1554UNSPECIFIED
Aung, Zaw WinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Yi FeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, LanyingUNSPECIFIEDorcid.org/0000-0002-5414-0055UNSPECIFIED
Lim, Tony Kiat HonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilm, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Choi, Poh SumUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ng, Poh YongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toh, Chee KeongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lim, Wan-TeckUNSPECIFIEDorcid.org/0000-0002-4655-0206UNSPECIFIED
Ma, SimingUNSPECIFIEDorcid.org/0000-0002-1810-8357UNSPECIFIED
Lim, BingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, JinUNSPECIFIEDorcid.org/0000-0002-5707-2078UNSPECIFIED
Tam, Wai LeongUNSPECIFIEDorcid.org/0000-0003-2365-5264UNSPECIFIED
Skanderup, Anders JacobsenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yeong, Joe Poh ShengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, Eng-HuatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Creasy, Caretha L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, Daniel Shao WengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillmer, Axel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhai, WeiweiUNSPECIFIEDorcid.org/0000-0001-7938-0226UNSPECIFIED
URN: urn:nbn:de:hbz:38-345642
DOI: 10.1038/s41588-019-0569-6
Journal or Publication Title: Nature Genet.
Volume: 52
Number: 2
Page Range: S. 177 - 200
Date: 2020
Publisher: NATURE PUBLISHING GROUP
Place of Publication: NEW YORK
ISSN: 1546-1718
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CANCER RISK; THERAPEUTIC TARGETS; MUTATIONS; EXPRESSION; DIVERSITY; HETEROGENEITY; MEN; DISCOVERY; FRAMEWORK; PATHWAYSMultiple languages
Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34564

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