Universität zu Köln

Maassen, Andreas ORCID: 0000-0002-1446-0994, Gebauer, Jan M., Abraham, Elena Theres, Grimm, Isabelle, Neudoerfl, Joerg-Martin, Kuehne, Ronald, Neundorf, Ines ORCID: 0000-0001-6450-3991, Baumann, Ulrich and Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 (2020). Triple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules. Angew. Chem.-Int. Edit., 59 (14). S. 5747 - 5756. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1521-3773

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Abstract

Collagen model peptides (CMPs) serve as tools for understanding stability and function of the collagen triple helix and have a potential for biomedical applications. In the past, interstrand cross-linking or conformational preconditioning of proline units through stereoelectronic effects have been utilized in the design of stabilized CMPs. To further study the effects determining collagen triple helix stability we investigated a series of CMPs containing synthetic diproline-mimicking modules (ProMs), which were preorganized in a PPII-helix-type conformation by a functionalizable intrastrand C-2 bridge. Results of CD-based denaturation studies were correlated with calculated (DFT) conformational preferences of the ProM units, revealing that the relative helix stability is mainly governed by an interplay of main-chain preorganization, ring-flip preference, adaptability, and steric effects. Triple helix integrity was proven by crystal structure analysis and binding to HSP47.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maassen, Andreas UNSPECIFIED orcid.org/0000-0002-1446-0994 UNSPECIFIED Gebauer, Jan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Abraham, Elena Theres UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimm, Isabelle UNSPECIFIED UNSPECIFIED UNSPECIFIED Neudoerfl, Joerg-Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuehne, Ronald UNSPECIFIED UNSPECIFIED UNSPECIFIED Neundorf, Ines UNSPECIFIED orcid.org/0000-0001-6450-3991 UNSPECIFIED Baumann, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalz, Hans-Guenther UNSPECIFIED orcid.org/0000-0003-0489-1827 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-345671
DOI:	10.1002/anie.201914101
Journal or Publication Title:	Angew. Chem.-Int. Edit.
Volume:	59
Number:	14
Page Range:	S. 5747 - 5756
Date:	2020
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1521-3773
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEREOSELECTIVE-SYNTHESIS; CRYSTAL-STRUCTURE; DESIGN; DIHYDROXYLATION; FLEXIBILITY; HSP47 Multiple languages Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/34567