Universität zu Köln

Gries, Raphael, Sala, Claudia ORCID: 0000-0003-4031-4648 and Rybniker, Jan ORCID: 0000-0001-8351-2690 (2020). Host-Directed Therapies and Anti-Virulence Compounds to Address Anti-Microbial Resistant Tuberculosis Infection. Appl. Sci.-Basel, 10 (8). BASEL: MDPI. ISSN 2076-3417

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Abstract

Despite global efforts to contain tuberculosis (TB), the disease remains a leading cause of morbidity and mortality worldwide, further exacerbated by the increased resistance to antibiotics displayed by the tubercle bacillus Mycobacterium tuberculosis. In order to treat drug-resistant TB, alternative or complementary approaches to standard anti-TB regimens are being explored. An area of active research is represented by host-directed therapies which aim to modulate the host immune response by mitigating inflammation and by promoting the antimicrobial activity of immune cells. Additionally, compounds that reduce the virulence of M. tuberculosis, for instance by targeting the major virulence factor ESX-1, are being given increased attention by the TB research community. This review article summarizes the current state of the art in the development of these emerging therapies against TB.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gries, Raphael UNSPECIFIED UNSPECIFIED UNSPECIFIED Sala, Claudia UNSPECIFIED orcid.org/0000-0003-4031-4648 UNSPECIFIED Rybniker, Jan UNSPECIFIED orcid.org/0000-0001-8351-2690 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-345857
DOI:	10.3390/app10082688
Journal or Publication Title:	Appl. Sci.-Basel
Volume:	10
Number:	8
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3417
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; INTERFERON-GAMMA; RETINOIC ACID; IMMUNE-RESPONSES; AUTOPHAGY; PROTEIN; ACTIVATION; INHIBITION; EXPRESSION Multiple languages Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Physics, Applied Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34585