Universität zu Köln

Shymanskaya, Aliaksandra ORCID: 0000-0001-7251-9539, Worthoff, Wieland A., Stoffels, Gabriele, Lindemeyer, Johannes ORCID: 0000-0003-4756-7947, Neumaier, Bernd, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Shah, N. Jon ORCID: 0000-0002-8151-6169 (2020). Comparison of [F-18]Fluoroethyltyrosine PET and Sodium MRI in Cerebral Gliomas: a Pilot Study. Mol. Imaging. Biol., 22 (1). S. 198 - 208. NEW YORK: SPRINGER. ISSN 1860-2002

Full text not available from this repository.

Abstract

Purpose Positron emission tomography (PET) using O-(2-[F-18]fluoroethyl)-L-tyrosine ([F-18]FET) improves the diagnostics of cerebral gliomas compared with conventional magnetic resonance imaging (MRI). Sodium MRI is an evolving method to assess tumor metabolism. In this pilot study, we explored the relationship of [F-18]FET-PET and sodium MRI in patients with cerebral gliomas in relation to the mutational status of the enzyme isocitrate dehydrogenase (IDH). Procedures Ten patients with untreated cerebral gliomas and one patient with a recurrent glioblastoma (GBM) were investigated by dynamic [F-18]FET-PET and sodium MRI using an enhanced simultaneous single-quantum- and triple-quantum-filtered imaging of Na-23 (SISTINA) sequence to estimate total (NaT), weighted non-restricted (NaNR, mainly extracellular), and restricted (NaR, mainly intracellular) sodium in tumors and normal brain tissue. [F-18]FET uptake and sodium parameters in tumors with a different IDH mutational status were compared. After biopsy or resection, histology and the IDH mutational status were determined neuropathologically. Results NaT (p = 0.05), tumor-to-brain ratios (TBR) of NaT (p = 0.02), NaNR (p = 0.003), and the ratio of NaT/NaR (p < 0.001) were significantly higher in IDH-mutated than in IDH-wild-type gliomas (n = 5 patients each) while NaR was significantly lower in IDH-mutated gliomas (p = 0.01). [F-18]FET parameters (TBR, time-to-peak) were not predictive of IDH status in this small cohort of patients. There was no obvious relationship between sodium distribution and [F-18]FET uptake. The patient with a recurrent GBM exhibited an additional radiation injury with strong abnormalities in sodium MRI. Conclusions Sodium MRI appears to be more strongly related to the IDH mutational status than are [F-18]FET-PET parameters. A further evaluation of the combination of the two methods in a larger group of high- and low-grade gliomas seems promising.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shymanskaya, Aliaksandra UNSPECIFIED orcid.org/0000-0001-7251-9539 UNSPECIFIED Worthoff, Wieland A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Lindemeyer, Johannes UNSPECIFIED orcid.org/0000-0003-4756-7947 UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Shah, N. Jon UNSPECIFIED orcid.org/0000-0002-8151-6169 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-347287
DOI:	10.1007/s11307-019-01349-y
Journal or Publication Title:	Mol. Imaging. Biol.
Volume:	22
Number:	1
Page Range:	S. 198 - 208
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1860-2002
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SINGLE-QUANTUM; F-18-FET PET; HUMAN BRAIN; TUMORS; RELAXATION; MIGRATION; SURVIVAL; HEALTH; PHASE Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34728