Universität zu Köln

Polanyi, Laura, Niessen, Carien M., Vohlen, Christina, Stinn, Julia, Kretschmer, Tobias ORCID: 0000-0002-4202-0806, Jentgen, Vanessa, Hirani, Dharmesh, Koningsbruggen-Rietschel, Silke V., Doetsch, Joerg and Alejandre Alcazar, Miguel A. (2020). Intrauterine growth restriction induces skin inflammation, increases TSLP and impairs epidermal barrier function. J. Mol. Med., 98 (2). S. 279 - 290. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1440

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Abstract

Intrauterine growth restriction (IUGR) and low birth weight are risk factors for childhood asthma. Atopic march describes the progression from early dermatitis to asthma during life. Since inflammatory signaling is linked to increased airway resistance and lung remodeling in rats after IUGR, we queried if these findings are related to skin inflammatory response. Firstly, we induced IUGR in Wistar rats by isocaloric protein restriction during gestation. IUGR rats showed lower body weight at postnatal day 1 (P1), catch-up growth at P21, and similar body weight like controls at P90. At P1 and P90, mRNA of inflammatory as well as fibrotic markers and number of skin immune cells (macrophages) were increased after IUGR. Skin thymic stromal lymphopoietin (TSLP) mRNA at P1 and serum TSLP at P1 and P21 were elevated in IUGR. Moreover, IUGR impaired transepidermal water loss at P21 and P90. IUGR induced higher. Secondly, the increase of TEWL after Oxazolone treatment as a model of atopic dermatitis (AD) was greater in IUGR than in Co. Our data demonstrate an early inflammatory skin response, which is linked to persistent macrophage infiltration in the skin and impaired epidermal barrier function after IUGR. These findings coupled with elevated TSLP could underlie atopic diseases in rats after IUGR. Key messages center dot The present study shows that IUGR increases macrophage infiltration and induces an inflammatory and fibrotic gene expression pattern in the skin of newborn rats. center dot Early postnatal inflammatory response in the skin after IUGR is followed by impaired epidermal barrier function later in life. center dot IUGR aggravates transepidermal water loss in an experimental atopic dermatitis model, possibly through elevated TSLP in skin and serum. center dot Early anti-inflammatory treatment and targeting TSLP signaling could offer novel avenues for early prevention of atopic disorders and late asthma in high-risk infants.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Polanyi, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Niessen, Carien M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vohlen, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Stinn, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Kretschmer, Tobias UNSPECIFIED orcid.org/0000-0002-4202-0806 UNSPECIFIED Jentgen, Vanessa UNSPECIFIED UNSPECIFIED UNSPECIFIED Hirani, Dharmesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Koningsbruggen-Rietschel, Silke V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Alejandre Alcazar, Miguel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-347491
DOI:	10.1007/s00109-019-01867-w
Journal or Publication Title:	J. Mol. Med.
Volume:	98
Number:	2
Page Range:	S. 279 - 290
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1440
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THYMIC STROMAL LYMPHOPOIETIN; ATOPIC-DERMATITIS; AIRWAY INFLAMMATION; SEVERE ASTHMA; BIRTH-WEIGHT; FETAL-GROWTH; IL-6; INTERLEUKIN-6; CELLS; DIFFERENTIATION Multiple languages Genetics & Heredity; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34749