Mavaddat, Nasim, Antoniou, Antonis C., Mooij, Thea M., Hooning, Maartje J., Heemskerk-Gerritsen, Bernadette A., Nogues, Catherine, Laborde, Lilian, Breysse, Emmanuel, Stoppa-Lyonnet, Dominique, Gauthier-Villars, Marion, Buecher, Bruno, Caron, Olivier, Fourme-Mouret, Emmanuelle, Fricker, Jean-Pierre, Lasset, Christine, Bonadona, Valerie, Berthet, Pascaline, Faivre, Laurence, Luporsi, Elisabeth, Mari, Veronique, Gladieff, Laurence, Gesta, Paul, Sobol, Hagay, Eisinger, Francois, Nogues, Catherine, Longy, Michel, Dugast, Catherine, Colas, Chrystelle, Coupier, Isabelle, Pujol, Pascal, Corsini, Carole, Lortholary, Alain, Vennin, Philippe, Adenis, Claude, Nguyen, Tan Dat, Delnatte, Capucine, Tinat, Julie, Tennevet, Isabelle, Limacher, Jean-Marc, Maugard, Christine, Bignon, Yves-Jean, Demange, Liliane, Penet, Clotilde, Dreyfus, Helene, Cohen-Haguenauer, Odile, Venat-Bouvet, Laurence, Leroux, Dominique, Dreyfus, Helene, Zattara-Cannoni, Helene, Fert-Ferrer, Sandra, Bera, Odile, Nogues, Catherine, Gauthier-Villars, Marion, Caron, Olivier, Gesta, Paul, Pujol, Pascal, Lortholary, Alain, Ellis, Steve, Ellis, Steve, Barrowdale, Daniel ORCID: 0000-0003-1661-3939, Frost, Debra, Evans, D. Gareth, Izatt, Louise, Adlard, Julian, Eeles, Ros, Brewer, Carole, Tischkowitz, Marc, Henderson, Alex, Cook, Jackie, Eccles, Diana, Hogervorst, F. B. L., Hogervorst, F. B. L., Collee, J. M., van Asperen, C. J., Mensenkamp, A. R., Ausems, M. G. E. M., Meijers-Heijboer, H. E. J., van Engelen, K., Blok, M. J., Oosterwijk, J. C., Verloop, J., van den Broek, E., van Engelen, Klaartje, Mourits, Marian J. E., Ausems, Margreet G. E. M., Koppert, Linetta B., Hopper, John L., John, Esther M., Chung, Wendy K., Andrulis, Irene L., Daly, Mary B., Buys, Saundra S., Benitez, Javier, Caldes, Trinidad, Jakubowska, Anna, Simard, Jacques, Singer, Christian F., Tan, Yen, Olah, Edith, Navratilova, Marie, Foretova, Lenka, Gerdes, Anne-Marie, Roos-Blom, Marie-Jose ORCID: 0000-0003-4066-607X, Van Leeuwen, Flora E., Arver, Brita, Olsson, Hakan ORCID: 0000-0002-8794-9635, Schmutzler, Rita K., Engel, Christoph ORCID: 0000-0002-7247-282X, Kast, Karin, Phillips, Kelly-Anne, Terry, Mary Beth, Milne, Roger L., Goldgar, David E., Rookus, Matti A., Andrieu, Nadine and Easton, Douglas F. (2020). Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers. Breast Cancer Res., 22 (1). LONDON: BMC. ISSN 1465-542X

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Abstract

Background The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially biased. Prospective studies have had limited power, particularly for BRCA2 mutation carriers. Further, previous studies have not considered the effect of RRSO in the context of natural menopause. Methods A multi-centre prospective cohort of 2272 BRCA1 and 1605 BRCA2 mutation carriers was followed for a mean of 5.4 and 4.9 years, respectively; 426 women developed incident breast cancer. RRSO was modelled as a time-dependent covariate in Cox regression, and its effect assessed in premenopausal and postmenopausal women. Results There was no association between RRSO and breast cancer for BRCA1 (HR = 1.23; 95% CI 0.94-1.61) or BRCA2 (HR = 0.88; 95% CI 0.62-1.24) mutation carriers. For BRCA2 mutation carriers, HRs were 0.68 (95% CI 0.40-1.15) and 1.07 (95% CI 0.69-1.64) for RRSO carried out before or after age 45 years, respectively. The HR for BRCA2 mutation carriers decreased with increasing time since RRSO (HR = 0.51; 95% CI 0.26-0.99 for 5 years or longer after RRSO). Estimates for premenopausal women were similar. Conclusion We found no evidence that RRSO reduces breast cancer risk for BRCA1 mutation carriers. A potentially beneficial effect for BRCA2 mutation carriers was observed, particularly after 5 years following RRSO. These results may inform counselling and management of carriers with respect to RRSO.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mavaddat, NasimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antoniou, Antonis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mooij, Thea M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooning, Maartje J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heemskerk-Gerritsen, Bernadette A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogues, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laborde, LilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breysse, EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoppa-Lyonnet, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gauthier-Villars, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buecher, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caron, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fourme-Mouret, EmmanuelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fricker, Jean-PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lasset, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonadona, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berthet, PascalineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faivre, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luporsi, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mari, VeroniqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gladieff, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gesta, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sobol, HagayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisinger, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogues, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Longy, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dugast, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colas, ChrystelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coupier, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pujol, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corsini, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lortholary, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vennin, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adenis, ClaudeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nguyen, Tan DatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delnatte, CapucineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tinat, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tennevet, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Limacher, Jean-MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maugard, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bignon, Yves-JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demange, LilianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penet, ClotildeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreyfus, HeleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cohen-Haguenauer, OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venat-Bouvet, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leroux, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreyfus, HeleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zattara-Cannoni, HeleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fert-Ferrer, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bera, OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogues, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gauthier-Villars, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caron, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gesta, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pujol, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lortholary, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellis, SteveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellis, SteveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrowdale, DanielUNSPECIFIEDorcid.org/0000-0003-1661-3939UNSPECIFIED
Frost, DebraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, D. GarethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Izatt, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adlard, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, RosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brewer, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tischkowitz, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henderson, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cook, JackieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eccles, DianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogervorst, F. B. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogervorst, F. B. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collee, J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Asperen, C. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mensenkamp, A. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ausems, M. G. E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meijers-Heijboer, H. E. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Engelen, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blok, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oosterwijk, J. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verloop, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Broek, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Engelen, KlaartjeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mourits, Marian J. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ausems, Margreet G. E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koppert, Linetta B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, John L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, Esther M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chung, Wendy K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, Irene L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daly, Mary B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buys, Saundra S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benitez, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caldes, TrinidadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakubowska, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simard, JacquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singer, Christian F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, YenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olah, EdithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navratilova, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foretova, LenkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerdes, Anne-MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roos-Blom, Marie-JoseUNSPECIFIEDorcid.org/0000-0003-4066-607XUNSPECIFIED
Van Leeuwen, Flora E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arver, BritaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olsson, HakanUNSPECIFIEDorcid.org/0000-0002-8794-9635UNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
Kast, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phillips, Kelly-AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Terry, Mary BethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milne, Roger L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldgar, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rookus, Matti A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrieu, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-348688
DOI: 10.1186/s13058-020-1247-4
Journal or Publication Title: Breast Cancer Res.
Volume: 22
Number: 1
Date: 2020
Publisher: BMC
Place of Publication: LONDON
ISSN: 1465-542X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WOMEN; METAANALYSIS; ASSOCIATION; CONSORTIUM; REDUCTION; SURVIVAL; KCONFAB; SURGERY; OVARIAN; LINKMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34868

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