Universität zu Köln

Tang, Chris C., Holtbernd, Florian, Ma, Yilong, Spetsieris, Phoebe, Oh, Alice, Fink, Gereon R., Timmermann, Lars, Eggers, Carsten and Eidelberg, David (2020). Hemispheric Network Expression in Parkinson's Disease: Relationship to Dopaminergic Asymmetries. J. Parkinsons Dis., 10 (4). S. 1737 - 1750. AMSTERDAM: IOS PRESS. ISSN 1877-718X

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Abstract

Background: Parkinson's disease (PD) is characterized by brain metabolic networks, specifically associated with motor and cognitive manifestations. Few studies have investigated network changes in cerebral hemispheres ipsilateral and contralateral to the clinically more affected body side. Objective: We examined hemispheric network abnormalities and their relationship to striatal dopaminergic deficits in PD patients at different stages. Methods: 45 PD patients underwent dual-tracer positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG) and F-18-fluorodopa (FDOPA) in a high-resolution PET scanner. In all patients, we computed expression levels for the PD-related motor/cognition metabolic patterns (PDRP/PDCP) as well as putamen/caudate FDOPA uptake values in both hemispheres. Resulting hemispheric measures in the PD group were compared with corresponding healthy control values and assessed across disease stages. Results: Hemispheric PDRP and PDCP expression was significantly elevated contralateral and ipsilateral to the more affected body side in patients with unilateral symptoms (H&Y 1: p <0.01) and in patients with bilateral limb involvement (H&Y 2-3: p <0.001; H&Y 4: p <0.003). Elevations in pattern expression were symmetrical at all disease stages. By contrast, FDOPA uptake in the caudate and putamen was reduced bilaterally (p < 0.002), with lower values on both sides at more advanced disease stages. Hemispheric uptake was asymmetrical in both striatal regions, with lower contralateral values at all disease stages. The magnitude of hemispheric uptake asymmetry was smaller with more advanced disease, reflecting greater change ipsilaterally. Conclusion: Symmetrical network expression in PD represents bilateral functional effects unrelated to nigrostriatal dopaminergic asymmetries.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tang, Chris C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtbernd, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ma, Yilong UNSPECIFIED UNSPECIFIED UNSPECIFIED Spetsieris, Phoebe UNSPECIFIED UNSPECIFIED UNSPECIFIED Oh, Alice UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Eidelberg, David UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-349713
DOI:	10.3233/JPD-202117
Journal or Publication Title:	J. Parkinsons Dis.
Volume:	10
Number:	4
Page Range:	S. 1737 - 1750
Date:	2020
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1877-718X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRAIN NETWORKS; ABNORMALITIES; PROGRESSION; VIOLATIONS Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34971