Universität zu Köln

Mueller, Theresa, Payton, Nicola M., Kalpouzos, Gregoria, Jessen, Frank, Grande, Giulia, Backman, Lars and Laukka, Erika J. (2020). Cognitive, Genetic, Brain Volume, and Diffusion Tensor Imaging Markers as Early Indicators of Dementia. J. Alzheimers Dis., 77 (4). S. 1443 - 1454. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: Although associated with dementia and cognitive impairment, microstructural white matter integrity is a rarely used marker of preclinical dementia. Objective: We aimed to evaluate the individual and combined effects of multiple markers, with special focus on microstructural white matter integrity, in detecting individuals with increased dementia risk. Methods: A dementia-free subsample (n = 212, mean age = 71.33 years) included in the population-based Swedish National Study on Aging and Care (SNAC-K) underwent magnetic resonance imaging (T1-weighted, fluid-attenuated inversion recovery, diffusion tensor imaging), neuropsychological testing (perceptual speed, episodic memory, semantic memory, letter and category fluency), and genotyping (APOE). Incident dementia was assessed during six years of follow-up. Results: A global model (global cognition, APOE, total brain tissue volume: AUC=0.920) rendered the highest predictive value for future dementia. Of the models based on specific markers, white matter integrity of the forceps major tract was included in the most predictive model, in combination with perceptual speed and hippocampal volume (AUC=0.911). Conclusion: Assessment of microstructural white matter integrity may improve the early detection of dementia, although the added benefit in this study was relatively small.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Payton, Nicola M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalpouzos, Gregoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Grande, Giulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Backman, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Laukka, Erika J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-349806
DOI:	10.3233/JAD-200445
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	77
Number:	4
Page Range:	S. 1443 - 1454
Date:	2020
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRECLINICAL ALZHEIMERS-DISEASE; WHITE-MATTER INTEGRITY; PREDICTS CONVERSION; IMPAIRMENT; MICROSTRUCTURE; INDIVIDUALS; PROGRESSION; DEFICITS; DECLINE; MEMORY Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34980