Universität zu Köln

Hamed, Kamal ORCID: 0000-0003-1896-9736, Engelhardt, Marc, Jones, Mark E., Saulay, Mikael, Holland, Thomas L., Seifert, Harald and Fowler, Vance G., Jr. (2020). Ceftobiprole versus daptomycin in Staphylococcus aureus bacteremia: a novel protocol for a double-blind, Phase III trial. Future Microbiol., 15 (1). S. 35 - 49. LONDON: FUTURE MEDICINE LTD. ISSN 1746-0921

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Abstract

Although Staphylococcus aureus is a common cause of bacteremia, treatment options are limited. The need for new therapies is particularly urgent for methicillin-resistant S. aureus bacteremia (SAB). Ceftobiprole is an advanced-generation, broad-spectrum cephalosporin with activity against both methicillin-susceptible and -resistant S. aureus. This is a Phase III, randomized, double-blind, active-controlled, parallel-group, multicenter, two-part study to establish the efficacy and safety of ceftobiprole compared with daptomycin in the treatment of SAB, including infective endocarditis. Anticipated enrollment is 390 hospitalized adult patients, aged >= 18 years, with confirmed or suspected complicated SAB. The primary end point is overall success rate. Target completion of the study is in the second half of 2021. Clinicaltrials.gov identifier: NCT03138733

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hamed, Kamal UNSPECIFIED orcid.org/0000-0003-1896-9736 UNSPECIFIED Engelhardt, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Jones, Mark E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saulay, Mikael UNSPECIFIED UNSPECIFIED UNSPECIFIED Holland, Thomas L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Fowler, Vance G., Jr. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-350890
DOI:	10.2217/fmb-2019-0332
Journal or Publication Title:	Future Microbiol.
Volume:	15
Number:	1
Page Range:	S. 35 - 49
Date:	2020
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1746-0921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METHICILLIN-RESISTANT; EXPERIMENTAL ENDOCARDITIS; CLINICAL MANAGEMENT; VANCOMYCIN; EPIDEMIOLOGY; INFECTIONS; GUIDELINES; THERAPY; MODEL Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35089