Universität zu Köln

Piepenbrock, Ellen, Higgins, Paul G. ORCID: 0000-0001-8677-9454, Wille, Julia, Xanthopoulou, Kyriaki ORCID: 0000-0001-8591-8184, Zweigner, Janine, Jahn, Peter, Reuter, Stefan, Skov, Robert ORCID: 0000-0002-6079-5381, Eichhorn, Joachim and Seifert, Harald (2020). Klebsiella variicola causing nosocomial transmission among neonates - an emerging pathogen? J. Med. Microbiol., 69 (3). S. 396 - 402. LONDON: MICROBIOLOGY SOC. ISSN 1473-5644

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Abstract

Introduction. Transmission of Enterobacterales in neonatal intensive care units (NICU) can cause outbreaks of colonization and invasive infections among neonates. Two clusters of nosocomial transmission of Klebsiella pneumoniae identified by MALDI-ToF mass-spectrometry were suspected at two NICUs in July and August 2016. Aim. To assess the potential transmission of K. pneumoniae among neonates. Methodology. Whole-genome sequencing (WGS) was performed of K. pneumoniae isolates obtained through targeted surveillance of patients and environmental sampling. Results. WGS data revealed that patient and environmental isolates represented two species, K. pneumoniae and K. variicola. Core-genome multi-locus sequence typing (cgMLST) of the isolates identified three separate transmission clusters, in Hospital A a cluster of K. pneumoniae isolates in 12 children and two environmental samples and a second cluster of K. variicola isolates in five children. In Hospital B a cluster of K. pneumoniae isolates from three children and five unrelated isolates of K. pneumoniae and two unrelated isolates of K. variicola were found. Conclusion. K. variicola can cause hospital outbreaks of colonization and infection similar to other Klebsiella spp.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Piepenbrock, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Higgins, Paul G. UNSPECIFIED orcid.org/0000-0001-8677-9454 UNSPECIFIED Wille, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Xanthopoulou, Kyriaki UNSPECIFIED orcid.org/0000-0001-8591-8184 UNSPECIFIED Zweigner, Janine UNSPECIFIED UNSPECIFIED UNSPECIFIED Jahn, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Skov, Robert UNSPECIFIED orcid.org/0000-0002-6079-5381 UNSPECIFIED Eichhorn, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-351120
DOI:	10.1099/jmm.0.001143
Journal or Publication Title:	J. Med. Microbiol.
Volume:	69
Number:	3
Page Range:	S. 396 - 402
Date:	2020
Publisher:	MICROBIOLOGY SOC
Place of Publication:	LONDON
ISSN:	1473-5644
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PNEUMONIAE; SEPSIS Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35112