Universität zu Köln

Eberwein, Philipp, Kroesser, Sonja and Steven, Philipp (2020). Semifluorinated Alkane Eye Drops in Chronic Ocular Graft-versus-Host Disease: A Prospective, Multicenter, Noninterventional Study. Ophthalmic Res., 63 (1). S. 50 - 59. BASEL: KARGER. ISSN 1423-0259

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Abstract

Purpose: Ocular graft-versus-host disease (oGvHD) following allogeneic hematopoietic stem cell transplantation develops as severe dry eye disease (DED) and is initially treated with lubricants, although no clinical trials are available using artificial tears in oGvHD. This trial was set up to test perfluorohexyloctane (NovaTears (R)) as nonpreserved layer-forming agent for the treatment of DED in oGvHD. Methods: 25 patients with severe DED due to oGvHD received 1 drop perfluorohexyloctane 4 times daily during a prospective, multicenter, observational 12-week study on top of established topical therapy. Clinical parameters included Schirmer test, tear film breakup time, corneal staining, meibum secretion and ocular surface disease index. Adverse events, visual acuity and intraocular pressure were key safety parameters. Results: From 25 patients recruited, 23 presented for the second visit. Perfluorohexyloctane treatment did not lead to any changes in clinical or safety parameters but led to fast relief in symptoms in 57% of the patients. One adverse reaction occurred. Conclusions: This study showed no change in clinical signs in severe DED due to oGvHD, which was not unexpected due to the underlying pathomechanisms. However, the study showed improvement of symptoms in individual patients allowing application of perfluorohexyloctane as an additional symptomatic therapy in oGvHD. (C) 2019 S. Karger AG, Basel.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eberwein, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroesser, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-351142
DOI:	10.1159/000499158
Journal or Publication Title:	Ophthalmic Res.
Volume:	63
Number:	1
Page Range:	S. 50 - 59
Date:	2020
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0259
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SEVERE DRY EYE; RISK-FACTORS; SURFACE; CORNEAL; GVHD; EXPRESSION; SEVERITY Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35114