Universität zu Köln

Wu, Xiaolin, Li, Jiahui, Gassa, Asmae, Buchner, Denise, Alakus, Hakan, Dong, Qiongzhu, Ren, Ning ORCID: 0000-0001-9776-2471, Liu, Ming, Odenthal, Margarete, Stippel, Dirk ORCID: 0000-0002-1107-0907, Bruns, Christiane, Zhao, Yue and Wahba, Roger (2020). Circulating tumor DNA as an emerging liquid biopsy biomarker for early diagnosis and therapeutic monitoring in hepatocellular carcinoma. Int. J. Biol. Sci., 16 (9). S. 1551 - 1563. LAKE HAVEN: IVYSPRING INT PUBL. ISSN 1449-2288

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Abstract

As one of the most common malignant tumors worldwide, hepatocellular carcinoma (HCC) is known for its poor prognosis due to diagnosis only in advanced stages. Nearly 50% of the patients with the first diagnosis of HCC die within a year. Currently, the advancements in the integration of omics information have begun to transform the clinical management of cancer patients. Molecular profiling for HCC patients is in general obtained from resected tumor materials or biopsies. However, the resected tumor tissue is limited and can only be obtained through surgery, so that dynamic monitoring of patients cannot be performed. Compared to invasive procedures, circulating tumor DNA (ctDNA) has been proposed as an alternative source to perform molecular profiling of tumor DNA in cancer patients. The detection of abnormal forms of circulating cell-free DNA (cfDNA) that originate from cancer cells (ctDNA) provides a novel tool for cancer detection and disease monitoring. This may also be an opportunity to optimize the early diagnosis of HCC. In this review, we summarized the updated methods, materials, storage of sampling, detection techniques for ctDNA and the comparison of the applications among different biomarkers in HCC patients. In particular, we analyzed ctDNA studies dealing with copy number variations, gene integrity, mutations (RAS, TERT, CTNNB1, TP53 and so on), DNA methylation alterations (DBX2, THY1, TGR5 and so on) for the potential utility of ctDNA in the diagnosis and management of HCC. The biological functions and correlated signaling pathways of ctDNA associated genes (including MAPK/RAS pathway, p53 signaling pathway and Wnt-beta catenin pathway) are also discussed and highlighted. Thus, exploration of ctDNA/cfDNA as potential biomarkers may provide a great opportunity in future liquid biopsy applications for HCC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wu, Xiaolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Jiahui UNSPECIFIED UNSPECIFIED UNSPECIFIED Gassa, Asmae UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchner, Denise UNSPECIFIED UNSPECIFIED UNSPECIFIED Alakus, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED Dong, Qiongzhu UNSPECIFIED UNSPECIFIED UNSPECIFIED Ren, Ning UNSPECIFIED orcid.org/0000-0001-9776-2471 UNSPECIFIED Liu, Ming UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, Margarete UNSPECIFIED UNSPECIFIED UNSPECIFIED Stippel, Dirk UNSPECIFIED orcid.org/0000-0002-1107-0907 UNSPECIFIED Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Yue UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahba, Roger UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-351260
DOI:	10.7150/ijbs.44024
Journal or Publication Title:	Int. J. Biol. Sci.
Volume:	16
Number:	9
Page Range:	S. 1551 - 1563
Date:	2020
Publisher:	IVYSPRING INT PUBL
Place of Publication:	LAKE HAVEN
ISSN:	1449-2288
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-FREE-DNA; 5-HYDROXYMETHYLCYTOSINE SIGNATURES; PROMOTER METHYLATION; SIGNALING PATHWAYS; CANCER-PATIENTS; MUTATIONS; SERUM; INSIGHTS; TGR5 Multiple languages Biochemistry & Molecular Biology; Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35126