Universität zu Köln

Zhao, Min, Luo, Jinqiang, Xiao, Bin, Tang, Hongyan, Song, Fanjun, Ding, Xiaolei and Yang, Guilan (2020). Endoplasmic reticulum stress links psoriasis vulgaris with keratinocyte inflammation. Postep. Dermatol. Alergol., 37 (1). S. 34 - 41. POZNAN: TERMEDIA PUBLISHING HOUSE LTD. ISSN 1642-395X

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Abstract

Introduction: Endoplasmic reticulum stress (ERS) has been implicated in the pathogenesis of various inflammatory diseases. However, the role of ERS in psoriasis is still unclear. Aim: To examine ERS in psoriasis keratinocytes and to assess the association of ERS with skin inflammation response. Material and methods: We investigated ERS in keratinocytes of normal skin, lesional and perilesional psoriasis vulgaris (PV) skin tissues using transmission electron microscope (TEM) examination, Western blot and immunostaining analysis. Results: By TEM examination, we found that endoplasmic reticulum (ER) in psoriatic keratinocytes was ultrastructurally abnormal, with changes in ER morphology and the ER expansion. Using Western blot and immunostaining analysis, we showed that the expression of ERS-associated proteins, such as BiP, CHOP and XBP1, was enhanced in PV epidermis compared to the healthy skin. Moreover, abundant TNF-alpha protein was correlated to the increased BiP, CHOP and XBP1 expression in PV epidermis. Conclusions: Our findings demonstrate that PV keratinocytes have an increased ERS, which may contribute to the pathogenesis of PV.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhao, Min UNSPECIFIED UNSPECIFIED UNSPECIFIED Luo, Jinqiang UNSPECIFIED UNSPECIFIED UNSPECIFIED Xiao, Bin UNSPECIFIED UNSPECIFIED UNSPECIFIED Tang, Hongyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Fanjun UNSPECIFIED UNSPECIFIED UNSPECIFIED Ding, Xiaolei UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Guilan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-351287
DOI:	10.5114/ada.2020.93382
Journal or Publication Title:	Postep. Dermatol. Alergol.
Volume:	37
Number:	1
Page Range:	S. 34 - 41
Date:	2020
Publisher:	TERMEDIA PUBLISHING HOUSE LTD
Place of Publication:	POZNAN
ISSN:	1642-395X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language KAPPA-B; PATHOGENESIS; ACTIVATION; PATHWAY; CELLS; SKIN Multiple languages Allergy; Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35128