Universität zu Köln

Laukamp, Kai Roman ORCID: 0000-0002-5600-5914, Lennartz, Simon, Ho, Vivian, Hokamp, Nils Grosse, Zopfs, David ORCID: 0000-0001-9978-7453, Gupta, Amit, Graner, Frank Philipp, Borggrefe, Jan ORCID: 0000-0003-2908-7560, Gilkeson, Robert and Ramaiya, Nikhil (2020). Evaluation of the liver with virtual non-contrast: single institution study in 149 patients undergoing TAVR planning. Br. J. Radiol., 93 (1106). LONDON: BRITISH INST RADIOLOGY. ISSN 1748-880X

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Abstract

Objective: To evaluate accuracy of virtual-non-contrast images (VNC) compared to true-unenhanced-images (TNC) for evaluation of liver attenuation acquired using spectral-detector CT (SDCT). Methods: 149 patients who underwent multiphase transcatheter-aortic-valve-replacement (TAVR) SDCT-examinations [unenhanced-chest (TNC), CT-angiography chest (CTA-chest, early arterial-phase) and abdomen (CTA-abdomen, additional early arterial-phase after a second injection of contrast media)] were retrospectively included. VNC of CTA-chest (VNC-chest) and CTA-abdomen (VNC-abdomen) were reconstructed and compared to TNC. Region of interest-based measurement of mean attenuation (Hounsfield unit, HU) was applied in the following regions: liver, spleen, abdominal aorta and paraspinal muscle. Results: VNC accuracy was high in the liver, spleen, abdominal aorta and muscle for abdomen-scanning. For the liver, average attenuation was 59.0 +/- 9.1 HU for TNC and 72.6 +/- 9,5 HU for CTA-abdomen. Liver attenuation in VNC-abdomen (59.1 +/- 6.4 HU) was not significantly different from attenuation in TNC (p > 0.05). In contrast, VNC was less accurate for chest-scanning: Due to the protocol, in CTA-chest no contrast media was present in the liver parenchyma as indicated by the same attenuation in TNC (59.0 +/- 9.1 HU) and CTA-chest (58.8 +/- 8.9 HU, p > 0.05). Liver attenuation in VNC-chest (56.2 +/- 6.4 HU, p < 0.05) was, however, significantly lower than in TNC and CTA-chest implying an artificial reduction of attenuation. Conclusion: VNC performed well in a large cohort of TAVR-examinations yielding equivalent mean attenuations to TNC; however, application of this technique might be limited when no or very little contrast media is present in parenchyma, more precisely in an early arterial-phase of the liver. Advances in knowledge: This study showed that VNC can be reliably applied in cardiac protocols when certain limitations are considered

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Laukamp, Kai Roman UNSPECIFIED orcid.org/0000-0002-5600-5914 UNSPECIFIED Lennartz, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Ho, Vivian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hokamp, Nils Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED Zopfs, David UNSPECIFIED orcid.org/0000-0001-9978-7453 UNSPECIFIED Gupta, Amit UNSPECIFIED UNSPECIFIED UNSPECIFIED Graner, Frank Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Borggrefe, Jan UNSPECIFIED orcid.org/0000-0003-2908-7560 UNSPECIFIED Gilkeson, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramaiya, Nikhil UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-351512
DOI:	10.1259/bjr.20190701
Journal or Publication Title:	Br. J. Radiol.
Volume:	93
Number:	1106
Date:	2020
Publisher:	BRITISH INST RADIOLOGY
Place of Publication:	LONDON
ISSN:	1748-880X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MACROVESICULAR HEPATIC STEATOSIS; ATTENUATION VALUES; UNITED-STATES; CT; PRINCIPLES; DIAGNOSIS; DONORS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35151