Universität zu Köln

Koulousakis, Philippos, van den Hove, Daniel, Visser-Vandewalle, Veerle and Sesia, Thibaut ORCID: 0000-0003-1761-4458 (2020). Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease: A Preliminary Approach. J. Alzheimers Dis., 73 (2). S. 461 - 467. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been shown to exert promising therapeutical effects in a pilot study with patients suffering from Alzheimer's disease (AD). We aimed at comparing the cognitive effects of intermittent and continuous NBM stimulation paradigms in an animal model for AD. In this exploratory study, aged Tgf344-AD rats were behaviorally tested pre-, and post implantation, while being stimulated with unilateral- or bilateral-intermittent and bilateral-continuous patterns. Bilateral-intermittent NBM DBS lead to supernormal performance in a spatial memory task. These findings suggest that NBM DBS could be further refined, thereby improving patient care.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koulousakis, Philippos UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Hove, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Sesia, Thibaut UNSPECIFIED orcid.org/0000-0003-1761-4458 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-351567
DOI:	10.3233/JAD-190919
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	73
Number:	2
Page Range:	S. 461 - 467
Date:	2020
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEURONS; BETA Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35156