Universität zu Köln

Maier, Berenike (2020). Competence and Transformation in Bacillus subtilis. Curr. Issues Mol. Biol., 37. S. 57 - 77. POOLE: CAISTER ACAD PRESS. ISSN 1467-3045

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Abstract

Transformation is the process of import and inheritable integration of DNA from the environment. As such, it is believed to be a major driving force for evolution. Competence for transformation is widespread among bacterial species. Recent findings draw a picture of a conserved molecular machine that binds DNA at the cell surface and subsequently transports it through the cell envelope. Within the cytoplasm the DNA is coated by proteins that mediate recombination or self-annealing. The regulatory mechanisms and environmental signals affecting competence are very diverse between different bacterial species. Competence in Bacillus subtilis has become a paradigm for stochastic determination of cell-fate. Quantitative analysis at the single cell level in conjunction with mathematical modelling allowed understanding of induction and decline of competence at the systems level. Currently, the picture is emerging of stochastic differentiation as a fitness trade-off in fluctuating environments.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maier, Berenike UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-351915
DOI:	10.21775/cimb.037.057
Journal or Publication Title:	Curr. Issues Mol. Biol.
Volume:	37
Page Range:	S. 57 - 77
Date:	2020
Publisher:	CAISTER ACAD PRESS
Place of Publication:	POOLE
ISSN:	1467-3045
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRIPTION FACTOR COMK; DEPENDENT QUORUM RESPONSE; SINGLE-STRANDED-DNA; GENETIC COMPETENCE; BINDING-SITE; K-STATE; NATURAL TRANSFORMATION; NEISSERIA-GONORRHOEAE; MICROARRAY ANALYSIS; PROMOTER REGION Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/35191