Universität zu Köln

Giehl, Kathrin ORCID: 0000-0002-0092-5164, Ophey, Anja ORCID: 0000-0001-5858-7762, Reker, Paul, Rehberg, Sarah P., Hammes, Jochen, Barbe, Michael T., Zokaei, Nahid, Eggers, Carsten, Husain, Masud ORCID: 0000-0002-6850-9255, Kalbe, Elke and van Eimeren, Thilo (2020). Effects of Home-Based Working Memory Training on Visuo-Spatial Working Memory in Parkinson's Disease: A Randomized Controlled Trial. J. Cent. Nerv. Syst. Dis., 12. LONDON: SAGE PUBLICATIONS LTD. ISSN 1179-5735

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Abstract

Background: Cognitive impairment is a very frequent and severe nonmotor symptom of Parkinson's disease (PD). Early intervention in this at-risk group for cognitive decline may be crucial for long-term preservation of cognitive functions. Computerized working memory training (WMT) has been proven beneficial in non-PD patient populations, but such evidence is still needed for patients with PD. Objective: This study aimed to evaluate the effect of WMT on visuo-spatial working memory (WM) in cognitively unimpaired patients with PD. Methods: A single-blind randomized controlled trial encompassing 76 patients with PD but no cognitive impairment according to level II diagnostic criteria was conducted. Thirty-seven patients engaged in home-based adaptive WMT 5 times per week for a period of 5 weeks, whereas the remaining patients were in the waiting list arm of the study (control group [CG]). Working memory performance was evaluated using a computerized task before and after intervention and at 14-week follow-up, allowing to quantify the precision of WM on a continuous scale, ie, to test not only if an item was remembered but also how well the location of this item was retained. Results: Coincidently, the WMT group showed slightly worse WM performance compared with the CG at baseline, which was ameliorated after WMT. This training-induced effect remained stable until follow-up. Conclusion: Patients showing relatively low WM performance, despite not formally diagnosable as Parkinson's disease with mild cognitive impairment (PD-MCI), seem to benefit from home-based WMT. Thus, WMT could potentially be implemented in future trials as a time- and cost-efficient route to counteract subtle cognitive changes in early disease stages.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Giehl, Kathrin UNSPECIFIED orcid.org/0000-0002-0092-5164 UNSPECIFIED Ophey, Anja UNSPECIFIED orcid.org/0000-0001-5858-7762 UNSPECIFIED Reker, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehberg, Sarah P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zokaei, Nahid UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Husain, Masud UNSPECIFIED orcid.org/0000-0002-6850-9255 UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-352137
DOI:	10.1177/1179573519899469
Journal or Publication Title:	J. Cent. Nerv. Syst. Dis.
Volume:	12
Date:	2020
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1179-5735
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; MILD COGNITIVE IMPAIRMENT; DEFICITS; BINDING; PRECISION; DECLINE Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35213