Universität zu Köln

Werner, Rudolf A., Derlin, Thorsten, Lapa, Constantin, Sheikbahaei, Sara, Higuchi, Takahiro ORCID: 0000-0001-9711-7835, Giesel, Frederik L., Behr, Spencer, Drzezga, Alexander, Kimura, Hiroyuki, Buck, Andreas K., Bengel, Frank M., Pomper, Martin G., Gorin, Michael A. and Rowe, Steven P. (2020). F-18-Labeled, PSMA-Targeted Radiotracers: Leveraging the Advantages of Radiofluorination for Prostate Cancer Molecular Imaging. Theranostics, 10 (1). S. 1 - 17. LAKE HAVEN: IVYSPRING INT PUBL. ISSN 1838-7640

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Abstract

Prostate-specific membrane antigen (PSMA)-targeted PET imaging for prostate cancer with Ga-68-labeled compounds has rapidly become adopted as part of routine clinical care in many parts of the world. However, recent years have witnessed the start of a shift from Ga-68- to F-18-labeled PSMA-targeted compounds. The latter imaging agents have several key advantages, which may lay the groundwork for an even more widespread adoption into the clinic. First, facilitated delivery from distant suppliers expands the availability of PET radiopharmaceuticals in smaller hospitals operating a PET center but lacking the patient volume to justify an onsite Ge-68/Ga-68 generator. Thus, such an approach meets the increasing demand for PSMA-targeted PET imaging in areas with lower population density and may even lead to cost-savings compared to in-house production. Moreover, F-18-labeled radiotracers have a higher positron yield and lower positron energy, which in turn decreases image noise, improves contrast resolution, and maximizes the likelihood of detecting subtle lesions. In addition, the longer half-life of 110 min allows for improved delayed imaging protocols and flexibility in study design, which may further increase diagnostic accuracy. Moreover, such compounds can be distributed to sites which are not allowed to produce radiotracers on-site due to regulatory issues or to centers without access to a cyclotron. In light of these advantageous characteristics, F-18-labeled PSMA-targeted PET radiotracers may play an important role in both optimizing this transformative imaging modality and making it widely available. We have aimed to provide a concise overview of emerging F-18-labeled PSMA-targeted radiotracers undergoing active clinical development. Given the wide array of available radiotracers, comparative studies are needed to firmly establish the role of the available F-18-labeled compounds in the field of molecular PCa imaging, preferably in different clinical scenarios.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Werner, Rudolf A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Derlin, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Lapa, Constantin UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheikbahaei, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Higuchi, Takahiro UNSPECIFIED orcid.org/0000-0001-9711-7835 UNSPECIFIED Giesel, Frederik L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Behr, Spencer UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Kimura, Hiroyuki UNSPECIFIED UNSPECIFIED UNSPECIFIED Buck, Andreas K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bengel, Frank M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pomper, Martin G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gorin, Michael A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rowe, Steven P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-352729
DOI:	10.7150/thno.37894
Journal or Publication Title:	Theranostics
Volume:	10
Number:	1
Page Range:	S. 1 - 17
Date:	2020
Publisher:	IVYSPRING INT PUBL
Place of Publication:	LAKE HAVEN
ISSN:	1838-7640
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; MEMBRANE ANTIGEN; F-18-DCFPYL PET/CT; RADIOLIGAND THERAPY; RADIATION-DOSIMETRY; INITIAL EVALUATION; BAY 1075553; T PET/CT; BIODISTRIBUTION; INHIBITOR Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35272