Universität zu Köln

Schulze-Rauschenbach, Svenja, Lennertz, Leonhard, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Petrovsky, Nadine, Ettinger, Ulrich ORCID: 0000-0002-0160-0281, Pukrop, Ralf, Dreher, Jan, Klosterkoetter, Joachim, Maier, Wolfgang and Wagner, Michael ORCID: 0000-0003-2589-6440 (2015). Neurocognitive functioning in parents of schizophrenia patients: Attentional and executive performance vary with genetic loading. Psychiatry Res., 230 (3). S. 885 - 892. CLARE: ELSEVIER IRELAND LTD. ISSN 0165-1781

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Abstract

Neuropsychological deficits are candidate endophenotypes of schizophrenia which can assist to explain the neurocognitive impact of genetic risk variants. The identification of endophenotypes is often based on the familiality of these phenotypes. Several studies demonstrate neuropsychological deficits in unaffected biological relatives of schizophrenia patients without differentiating between genetic and non-genetic factors underlying these deficits. We assessed N=129 unaffected biological parents of schizophrenia patients, N=28 schizophrenia patients (paranoid subtype), and N=143 controls without a family history of schizophrenia with an extensive neuropsychological test battery. Direct comparison of N=22 parents with an ancestral history of schizophrenia (more likely carriers, MLC) and N=17 of their spouses without such a history (less likely carriers, LLC) allowed the separation of genetic and non-genetic aspects in cognition. Overall, parents showed significant deficits in neuropsychological tasks from all cognitive domains with medium effect sizes. Direct comparisons of MLC- and LLC-parents showed that attentional and executive tasks were most strongly affected by genetic loading. To conclude, unaffected parents of schizophrenia patients showed modest yet significant impairments in attention, memory, and executive functioning. In particular, attentional and executive impairments varied most strongly with genetic loading for schizophrenia, prioritising these dysfunctions for genotype-endophenotype analyses. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schulze-Rauschenbach, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Lennertz, Leonhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Petrovsky, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Ettinger, Ulrich UNSPECIFIED orcid.org/0000-0002-0160-0281 UNSPECIFIED Pukrop, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreher, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-383467
DOI:	10.1016/j.psychres.2015.11.031
Journal or Publication Title:	Psychiatry Res.
Volume:	230
Number:	3
Page Range:	S. 885 - 892
Date:	2015
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	0165-1781
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUROPSYCHOLOGICAL DYSFUNCTION; COGNITIVE DEFICITS; ENDOPHENOTYPES; RELATIVES; MEMORY; VOLUME; TASKS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38346