Universität zu Köln

Valenzano, Dario Riccardo ORCID: 0000-0002-8761-8289, Benayoun, Berenice A., Singh, Param Priya, Zhang, Elisa, Etter, Paul D., Hu, Chi-Kuo, Clement-Ziza, Mathieu ORCID: 0000-0003-2763-249X, Willemsen, David, Cui, Rongfeng ORCID: 0000-0002-8146-6958, Harel, Itamar ORCID: 0000-0001-9749-8279, Machado, Ben E., Yee, Muh-Ching, Sharp, Sabrina C., Bustamante, Carlos D. ORCID: 0000-0002-4187-7920, Beyer, Andreas ORCID: 0000-0002-3891-2123, Johnson, Eric A. and Brunet, Anne (2015). The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan. Cell, 163 (6). S. 1539 - 1555. CAMBRIDGE: CELL PRESS. ISSN 1097-4172

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Abstract

Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan differences remain elusive. Here we de novo assemble a reference genome for the naturally short-lived African turquoise killifish, providing a unique resource for comparative and experimental genomics. The identification of genes under positive selection in this fish reveals potential candidates to explain its compressed lifespan. Several aging genes are under positive selection in this short-lived fish and long-lived species, raising the intriguing possibility that the same gene could underlie evolution of both compressed and extended lifespans. Comparative genomics and linkage analysis identify candidate genes associated with lifespan differences between various turquoise killifish strains. Remarkably, these genes are clustered on the sex chromosome, suggesting that short lifespan might have co-evolved with sex determination. Our study provides insights into the evolutionary forces that shape lifespan in nature.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Valenzano, Dario Riccardo UNSPECIFIED orcid.org/0000-0002-8761-8289 UNSPECIFIED Benayoun, Berenice A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Singh, Param Priya UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Elisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Etter, Paul D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Chi-Kuo UNSPECIFIED UNSPECIFIED UNSPECIFIED Clement-Ziza, Mathieu UNSPECIFIED orcid.org/0000-0003-2763-249X UNSPECIFIED Willemsen, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Cui, Rongfeng UNSPECIFIED orcid.org/0000-0002-8146-6958 UNSPECIFIED Harel, Itamar UNSPECIFIED orcid.org/0000-0001-9749-8279 UNSPECIFIED Machado, Ben E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yee, Muh-Ching UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharp, Sabrina C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bustamante, Carlos D. UNSPECIFIED orcid.org/0000-0002-4187-7920 UNSPECIFIED Beyer, Andreas UNSPECIFIED orcid.org/0000-0002-3891-2123 UNSPECIFIED Johnson, Eric A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brunet, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-383902
DOI:	10.1016/j.cell.2015.11.008
Journal or Publication Title:	Cell
Volume:	163
Number:	6
Page Range:	S. 1539 - 1555
Date:	2015
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4172
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FISH NOTHOBRANCHIUS FURZERI; HUMAN LONGEVITY; CAENORHABDITIS-ELEGANS; VERTEBRATE MODEL; MUTATIONS; PROGRANULIN; STRESS; RESISTANCE; ALIGNMENT; DATABASE Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38390