Universität zu Köln

Gnoth, Christian, Roos, Judith, Broomhead, David, Schiffner, Julia, Godehardt, Erhard, Freundl, Guenter and Johnson, Sarah (2015). Antimullerian hormone levels and numbers and sizes of antral follicles in regularly menstruating women of reproductive age referenced to true ovulation day. Fertil. Steril., 104 (6). S. 1535 - 1548. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1556-5653

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Abstract

Objective: To assess menstrual cycle antimullerian hormone (AMH) levels in reproductive age women and which/how many follicles substantially produce AMH. Design: Prospective study of menstruating women using mixed-effects models to analyze AMH variability and correlation of follicle counts/size classes to AMH levels. Setting: Clinic. Patient(s): Regular menstruating women with ovulatory cycles (n = 40, aged 18-37 years) and no known subfertility. Intervention(s): Women collected daily urine samples and visited the study center for blood samples/transvaginal ultrasound during one complete menstrual cycle (visits were every 2 days; daily from follicle size >16 mm until postovulation). Main Outcome Measure(s): AMH levels throughout the menstrual cycle, correlated with antral follicles as observed by ultrasound and identification of follicles producing AMH. Results: Of all antral follicles visible by high-resolution ultrasound, AMH is produced substantially only by follicles up to 7 mm in diameter. For women with basal AMH >1 ng/mL, mean AMH concentrations vary across ovulatory menstrual cycles, showing a statistically significant decrease from -5 to 2 days after objective ovulation; significantly lower mean luteal AMH levels (-7.59% to mean follicular AMH) are detected. The number of antral follicles can be estimated from AMH (ng/mL) levels using the modified Beckman Coulter Generation II AMH assay for any day of the follicular phase. Conclusion(s): AMH concentrations vary across ovulatory menstrual cycles, showing a significant periovulatory decrease. The number of small antral follicles can be estimated from preovulatory AMH levels with relevance for patient management. (C) 2015 by American Society for Reproductive Medicine.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gnoth, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Roos, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Broomhead, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffner, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Godehardt, Erhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Freundl, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED Johnson, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-384611
DOI:	10.1016/j.fertnstert.2015.08.027
Journal or Publication Title:	Fertil. Steril.
Volume:	104
Number:	6
Page Range:	S. 1535 - 1548
Date:	2015
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1556-5653
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTI-MULLERIAN HORMONE; MLLERIAN HORMONE; AMH; CYCLE; ULTRASOUND; PHYSIOLOGY; ASSAY; PCOS Multiple languages Obstetrics & Gynecology; Reproductive Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38461