Universität zu Köln

Franz, Andre, Kevei, Eva ORCID: 0000-0002-0560-9208 and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2015). Double-edged alliance: mitochondrial surveillance by the UPS and autophagy. Curr. Opin. Cell Biol., 37. S. 18 - 28. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0410

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Abstract

Mitochondria provide an essential role in the maintenance of cellular homeostasis with regard to energy generation, redox signaling, and programmed cell death. Consequently, fast adaptation to metabolic changes associated with developmental demands or stress induction requires a balanced coordination of mitochondrial biogenesis and removal of damaged mitochondria. Impaired mitochondrial maintenance is causally linked to many human pathologies and aging, including diabetes, cancer, and neurodegenerative diseases. Thus, it is of fundamental importance to understand cellular surveillance mechanisms that support a healthy mitochondrial network. In this review, we discuss the role of ubiquitin-dependent protein degradation in mitochondrial functionality.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Franz, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Kevei, Eva UNSPECIFIED orcid.org/0000-0002-0560-9208 UNSPECIFIED Hoppe, Thorsten UNSPECIFIED orcid.org/0000-0002-4734-9352 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-384990
DOI:	10.1016/j.ceb.2015.08.004
Journal or Publication Title:	Curr. Opin. Cell Biol.
Volume:	37
Page Range:	S. 18 - 28
Date:	2015
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0410
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNFOLDED PROTEIN RESPONSE; UBIQUITIN-PROTEASOME SYSTEM; C-ELEGANS; DAMAGED MITOCHONDRIA; MAMMALIAN-CELLS; ACTIVATE PARKIN; OUTER-MEMBRANE; MITOPHAGY; PINK1; DEGRADATION Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/38499