Universität zu Köln

Siemanowski, Janna, Richter, Tobias and Bucher, Gregor (2015). Notch signaling induces cell proliferation in the labrum in a regulatory network different from the thoracic legs. Dev. Biol., 408 (1). S. 164 - 178. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-564X

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Abstract

The insect head is composed of several segments and an anterior non-segmental region. While patterning of the segmental region relies - at least in part - on the known trunk patterning mechanisms, development of the anterior most region remains poorly understood. The labrum is an enigmatic structure of the anterior median region (AMR) of the insect head. Based on similar development and gene expression patterns it has been suggested to be a serial homolog of trunk appendages. However, its position in the non-segmental region indicated an independent origin. In order to learn more about development of the AMR including the labrum, we screened the results of the large scale RNAi screen iBeetle to identify novel genes. We found the Notch ligand Tc-Serrate and the ubiquitin ligase Tc-mind bomb1 to be required for labrum formation. Further studies showed that Notch signaling is acting upstream of the genetic hierarchy and is required for regulating cell proliferation. We combined our work with previous data to compare the regulatory gene networks of labrum and trunk appendage formation. This reveals that despite the involvement of a similar set of genes, the genetic interactions are quite different. (C) 2015 The Authors. Published by Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Siemanowski, Janna UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Bucher, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-385002
DOI:	10.1016/j.ydbio.2015.09.018
Journal or Publication Title:	Dev. Biol.
Volume:	408
Number:	1
Page Range:	S. 164 - 178
Date:	2015
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-564X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BEETLE TRIBOLIUM-CASTANEUM; RED FLOUR BEETLE; SHORT GERM INSECT; DROSOPHILA-MELANOGASTER; MIND BOMB; DISTAL-LESS; APPENDAGE DEVELOPMENT; LIGAND ENDOCYTOSIS; UBIQUITIN LIGASE; RNAI PHENOTYPES Multiple languages Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38500