Universität zu Köln

Tahmasian, Masoud ORCID: 0000-0003-3999-3807, Bettray, Lisa M., van Eimeren, Thilo ORCID: 0000-0002-6951-2325, Drzezga, Alexander, Timmermann, Lars, Eickhoff, Claudia R., Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 and Eggers, Carsten (2015). A systematic review on the applications of resting-state fMRI in Parkinson's disease: Does dopamine replacement therapy play a role? Cortex, 73. S. 80 - 106. PARIS: ELSEVIER MASSON, CORPORATION OFFICE. ISSN 1973-8102

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Abstract

Functional neuroimaging techniques provide important insight into the pathophysiology of neurodegenerative disorders such as Parkinson's disease (PD) in-vivo. Recently, resting-state functional magnetic resonance imaging (rs-fMRI) has been applied as a non-invasive tool in many studies to assess functional abnormalities observed in PD without the effects of particular motor or cognitive tasks. In this review, we summarized 50 original PD rs-fMRI studies and subdivided them based on the medication status of the patients to highlight the impact of dopamine replacement therapy (DRT) when rs-fMRI was used to assess patients with PD. Although there are many different published approaches to analyzing rs-fMRI in PD, it seems that DRT plays a critical role in the functional reorganization of the brain throughout all of these approaches. In particular, studies that compared PD patients with and without medication demonstrated that DRT normalizes aberrant functional patterns in PD and leads to an improvement of PD symptoms. Thus, researchers should consider DRT as a confounding factor, which could result in misinterpretations. We suggest that performing rs-fMRI in de novo patients could be a method of choice to study the fundamental functional abnormalities in PD independent of the effects of DRT. However, it is necessary to carefully control for excessive involuntary head motions in the patients not receiving DRT. On the other hand, recruiting patients under daily DRT might be favorable to assess particular interventions in clinical routine. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tahmasian, Masoud UNSPECIFIED orcid.org/0000-0003-3999-3807 UNSPECIFIED Bettray, Lisa M. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED orcid.org/0000-0002-6951-2325 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Claudia R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-385838
DOI:	10.1016/j.cortex.2015.08.005
Journal or Publication Title:	Cortex
Volume:	73
Page Range:	S. 80 - 106
Date:	2015
Publisher:	ELSEVIER MASSON, CORPORATION OFFICE
Place of Publication:	PARIS
ISSN:	1973-8102
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEFAULT-MODE NETWORK; CORTICO-STRIATAL CONNECTIVITY; FUNCTIONAL BRAIN NETWORKS; BASAL GANGLIA CIRCUITS; DRUG-NAIVE PATIENTS; REGIONAL HOMOGENEITY; ALZHEIMERS-DISEASE; GLOBAL SIGNAL; MOTOR CORTEX; AMPLITUDE Multiple languages Behavioral Sciences; Neurosciences; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38583