Universität zu Köln

Mueller, Ulf J., Truebner, Kurt, Schiltz, Kolja, Kuhn, Jens, Mawrin, Christian, Dobrowolny, Henrik, Bernstein, Hans-Gert, Bogerts, Bernhard and Steiner, Johann ORCID: 0000-0002-2611-2268 (2015). Postmortem volumetric analysis of the nucleus accumbens in male heroin addicts: implications for deep brain stimulation. Eur. Arch. Psych. Clin. Neurosci., 265 (8). S. 647 - 654. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is increasingly investigated in neuropsychiatric disorders. DBS requires computer-assisted 3D planning to implant the stimulation electrode precisely. Recently, there has been a debate about the true dimensions of NAc in healthy as well as in mentally ill individuals. Knowing its true dimensions in different neuropsychiatric disorders may improve even more precise targeting of NAc for therapeutic DBS. Volumes of NAc of heroin addicts (n = 14) and healthy controls (n = 12) were calculated by using morphometry of serial whole-brain sections. Total brain volume was larger in the heroin group (mean 1478.85 +/- A 62.34 vs. mean 1352.38 +/- A 103.24 cm(3)), as the heroin group was more than 10 years younger (p = 0.001). However, the mean volume of the NAc in heroin addicts was smaller than in controls (0.528 +/- A 0.166 vs. 0.623 +/- A 0.196 cm(3); p = 0.019). This group effect did not significantly differ between the hemispheres. When assessed separately, left-hemispheric NAc volume was 15 % lower (p = 0.020), while right-hemispheric NAc volume was 16 % lower (p = 0.047) in the heroin-addicted group compared to controls. Based on these diagnosis-related differences, we believe it is important to further analyze NAc volumes in different psychiatric disorders to further improve precise targeting and electrode placement.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Ulf J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Truebner, Kurt UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiltz, Kolja UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Mawrin, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Dobrowolny, Henrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Bernstein, Hans-Gert UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogerts, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Steiner, Johann UNSPECIFIED orcid.org/0000-0002-2611-2268 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386582
DOI:	10.1007/s00406-015-0617-x
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	265
Number:	8
Page Range:	S. 647 - 654
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOOD DISORDERS; PARAVENTRICULAR NUCLEUS; REWARD CIRCUITRY; SHELL; DEPENDENCE; OUTCOMES; NEURONS; SYSTEM Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38658