Universität zu Köln

Teutsch, K., Schweitzer, F., Knops, E., Kaiser, R., Pfister, H., Verheyen, J., Goebel, H., Cingoez, T. and Di Cristanziano, V. (2015). Early identification of renal transplant recipients with high risk of polyomavirus-associated nephropathy. Med. Microbiol. Immunol., 204 (6). S. 657 - 665. NEW YORK: SPRINGER. ISSN 1432-1831

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Abstract

Polyomavirus BK (BKPyV) is ubiquitous among humans. Following primary infection, the virus remains latent predominantly in the hosts' uroepithelial cells. Up to 10 % of renal transplant recipients show a viral reactivation that can lead to polyomavirus-associated nephropathy (PyVAN). In the absence of early treatments, the risk of graft loss is up to 80 %. Monitoring viral load in urine and plasma by real-time PCR after transplantation is the most common diagnostic tool to detect viral reactivation. In the present retrospective study, BKPyV-DNA loads in urine and plasma by quantitative real-time PCR were associated with clinical data, including HLA haplotype, blood parameters and viral genotype, of 40 renal transplant recipients at the University Clinics of Cologne. Seventeen out of 329 patients screened for BKPyV from January 2009 to October 2013 were detected BKPyV positive in urine only, whereas in 23 patients the virus became additionally detectable in plasma. Among these, ten patients progressed to PyVAN. Overall, the present study showed that the detection from the third month onwards after transplantation of a first viruric episode with a median viral load of 1 x 10(8) copies/mL, followed after few days by a first viremic episode with a median viral load of > 1 x 10(4) copies/mL, was strongly associated with the development of PyVAN. In conclusion, the viral load and the temporal profile of the first viruric and viremic episode post-transplantation, in combination with specific features of the host immune response, should be considered as relevant clinical determinants of the risk of renal transplant recipients to progress to PyVAN.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Teutsch, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schweitzer, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knops, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Verheyen, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goebel, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cingoez, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386638
DOI:	10.1007/s00430-015-0398-x
Journal or Publication Title:	Med. Microbiol. Immunol.
Volume:	204
Number:	6
Page Range:	S. 657 - 665
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1831
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BK VIRUS NEPHROPATHY; VIRAL LOAD; CLINICAL-COURSE; INFECTION; VP1; REPLICATION; POPULATIONS; PREVALENCE; MUTATIONS; PATHOGEN Multiple languages Immunology; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38663