Universität zu Köln

Rembe, Julian-Dario ORCID: 0000-0002-5176-6941, Boehm, Julia K., Fromm-Dornieden, Carolin, Schaefer, Nadine, Maegele, Marc, Froehlich, Matthias and Stuermer, Ewa K. (2015). Comparison of hemostatic dressings for superficial wounds using a new spectrophotometric coagulation assay. J. Transl. Med., 13. LONDON: BMC. ISSN 1479-5876

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Abstract

Background: Due to demographical changes the number of elderly patients depending on oral anticoagulation is expected to rise. Prolonged bleeding times in case of traumatic injuries represent the drawback of these medications, not only in major trauma, but also in superficial wounds. Therefore, dressings capable of accelerating coagulation onset and shortening bleeding times are desirable for these patients. Methods: The hemostatic potential and physical properties of different types of superficial wound dressings (standard wound pad, two alginates, chitosan, collagen (Lyostypt (R)), oxidized cellulose, and QuikClot (R)) were assessed in vitro. For this purpose the clotting times of blood under the influence of the named hemostatics from healthy volunteers were compared with Marcumar (R) or ASS (R) treated patients. For that, a newly developed coagulation assay based on spectrophotometric extinction measurements of thrombin activity was used. Results: The fastest coagulation onset was observed for oxidized cellulos (empty set 2.47 min), Lantor alginate-L (empty set 2.50 min) and QuikClot (R) (empty set 3.01 min). Chitosan (empty set 5.32 min) and the collagen Lyostypt (R) (empty set 7.59 min) induced clotting comparatively late. Regarding physical parameters, QuikClot (R) showed the lowest absorption capacity and speed while chitosan and both alginates achieved the highest. While oxidized cellulose displayed the best clotting times, unfortunately it also revealed low absorption capacity. Conclusions: All tested specimens seem to induce clotting independently from the administered type of oral anticoagulant, providing the possibility to neglect the disadvantage in clotting times arising from anticoagulation on a local basis. QuikClot (R), oxidized cellulose and unexpectedly alginate-L were superior to chitosan and Lyostypt (R). Due to its additional well-known positive effect on wound healing alginate-L should be considered for further investigations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rembe, Julian-Dario UNSPECIFIED orcid.org/0000-0002-5176-6941 UNSPECIFIED Boehm, Julia K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fromm-Dornieden, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Maegele, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Froehlich, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuermer, Ewa K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386694
DOI:	10.1186/s12967-015-0740-5
Journal or Publication Title:	J. Transl. Med.
Volume:	13
Date:	2015
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1479-5876
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATRIAL-FIBRILLATION; HEMORRHAGE CONTROL; AGENTS; MODEL; SKIN; COLLAGEN; BLOOD; ANTICOAGULATION; ALGINATE; EFFICACY Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38669