Schoettle, Jakob, Chatterjee, Sampurna, Volz, Caroline, Siobal, Maike, Florin, Alexandra, Rokitta, Dennis, Hinze, Yvonne, Dietlein, Felix, Plenker, Dennis, Koenig, Katharina, Albus, Kerstin, Heuckmann, Johannes M., Rauh, Daniel ORCID: 0000-0002-1970-7642, Franz, Thomas, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Fuhr, Uwe, Heukamp, Lukas C. and Ullrich, Roland T. (2015). Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer. Oncotarget, 6 (36). S. 38458 - 38469. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

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Abstract

Treatment with EGFR kinase inhibitors improves progression-free survival of patients with EGFR-mutant lung cancer. However, all patients with initial response will eventually acquire resistance and die from tumor recurrence. We found that intermittent high-dose treatment with erlotinib induced apoptosis more potently and improved tumor shrinkage significantly than the established low doses. In mice carrying EGFR-mutant xenografts intermittent high-dose treatment (200 mg/kg every other day) was tolerable and prolonged progression-free survival and reduced the frequency of acquired resistance. Intermittent EGFR-targeted high-dose schedules induce more profound as well as sustained target inhibition and may afford enhanced therapeutic efficacy.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schoettle, JakobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chatterjee, SampurnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volz, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siobal, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Florin, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rokitta, DennisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hinze, YvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dietlein, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plenker, DennisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albus, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heuckmann, Johannes M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauh, DanielUNSPECIFIEDorcid.org/0000-0002-1970-7642UNSPECIFIED
Franz, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDorcid.org/0000-0001-5425-3116UNSPECIFIED
Fuhr, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heukamp, Lukas C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ullrich, Roland T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-386903
DOI: 10.18632/oncotarget.6276
Journal or Publication Title: Oncotarget
Volume: 6
Number: 36
Page Range: S. 38458 - 38469
Date: 2015
Publisher: IMPACT JOURNALS LLC
Place of Publication: ORCHARD PARK
ISSN: 1949-2553
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GROWTH-FACTOR RECEPTOR; POSITRON-EMISSION-TOMOGRAPHY; ACQUIRED-RESISTANCE; KINASE INHIBITORS; T790M MUTATIONS; GEFITINIB; AMPLIFICATION; ADENOCARCINOMAS; CARBOPLATIN; ACTIVATIONMultiple languages
Oncology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38690

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